Evidence map›Paper›PMID 40806180›Full record

ArticleInternational journal of molecular sciences2025

Antibacterial and Antifungal Tannic Acid Coating on Plasma-Activated Titanium Alloy Surface.

Mariusz Winiecki, Magdalena Stepczyńska, Maciej Walczak, Ewelina Soszczyńska, Magdalena Twarużek, Dorota Bociaga, Marek Trzcinski, Marta Michalska-Sionkowska, Krzysztof Moraczewski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariusz WinieckiDepartment of Constructional Materials and Biomaterials, Faculty of Materials Engineering, Kazimierz Wielki University, 30 Chodkiewicza Street, 85-064 Bydgoszcz, Poland.ORCID 0000-0002-3568-2473
Magdalena StepczyńskaDepartment of Polymer Materials Engineering, Faculty of Materials Engineering, Kazimierz Wielki University, 30 Chodkiewicza Street, 85-064 Bydgoszcz, Poland.ORCID 0000-0002-9728-5633
Maciej WalczakDepartment of Environmental Microbiology and Biotechnology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 1 Lwowska Street, 87-100 Torun, Poland.
Ewelina SoszczyńskaDepartment of Physiology and Toxicology, Faculty of Biological Sciences, Kazimierz Wielki University, 30 Chodkiewicza Street, 85-064 Bydgoszcz, Poland.ORCID 0000-0002-7122-0401
Magdalena TwarużekDepartment of Physiology and Toxicology, Faculty of Biological Sciences, Kazimierz Wielki University, 30 Chodkiewicza Street, 85-064 Bydgoszcz, Poland.ORCID 0000-0002-2568-1178
Dorota BociagaInstitute of Materials Science and Engineering, Faculty of Mechanical Engineering, Lodz University of Technology, 1/15 Stefanowskiego Street, 90-537 Lodz, Poland.ORCID 0000-0001-6230-4219
Marek TrzcinskiDivision of Surface Science, Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, 7 Prof. S. Kaliskiego Avenue, 85-796 Bydgoszcz, Poland.
Marta Michalska-SionkowskaDepartment of Environmental Microbiology and Biotechnology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 1 Lwowska Street, 87-100 Torun, Poland.ORCID 0000-0002-5851-734X
Krzysztof MoraczewskiDepartment of Polymer Materials Engineering, Faculty of Materials Engineering, Kazimierz Wielki University, 30 Chodkiewicza Street, 85-064 Bydgoszcz, Poland.ORCID 0000-0003-4188-8408

Funding

Ministry of Science and Higher Education RID/SP/0048/2024/01
6 · The paper itself

Abstract

Titanium (Ti) alloys, renowned for their exceptional physicochemical properties and high biocompatibility, are widely utilized in orthopedic and dental implants; however, their lack of intrinsic antimicrobial activity significantly increases the risk of implant-associated infections, often leading to severe complications and implant failure. Developing antimicrobial coatings on Ti implants is therefore a promising strategy. In this study, tannic acid (TA) coatings were deposited by immersing Ti alloy surfaces-beforehand activated by low-temperature oxygen plasma-in TA solutions at 2, 5, and 8 wt%. Coatings were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), water contact angle (WCA) measurements, and Folin-Ciocalteu release assays, and their cytocompatibility and antimicrobial performance were assessed in vitro. Surface characterization confirmed the formation of uniform TA layers, and WCA measurements indicated enhanced hydrophilicity relative to unmodified Ti (82.0° ± 3.6°), with values decreasing as TA concentration increased (from 35.2° ± 3.2° for 2% TA to 26.6° ± 2.8° for 8% TA). TA release profiles exhibited an initial burst followed by sustained diffusion, with 5% and 8% coatings releasing significantly more TA than 2% coatings. Coatings containing ≥ 5% TA demonstrated bactericidal activity-achieving > 2-log

Indexed as

AlloysAnti-Bacterial AgentsAntifungal AgentsCoated Materials, BiocompatibleTanninsTitaniumAnimalsCandida albicansEscherichia coliMiceMicrobial Sensitivity TestsNIH 3T3 CellsPlasma GasesPolyphenolsStaphylococcus aureusSurface PropertiesAlloysAnti-Bacterial AgentsAntifungal AgentsCoated Materials, BiocompatiblePlasma GasesPolyphenolstannic acidTanninsTitaniumantibacterialantifungalcoatingssurface modificationsurface propertiestannic acidtitanium alloy

Identifiers

PMID40806180
PMCPMC12346454

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.