Evidence map›Paper›PMID 40806170›Full record

ArticleInternational journal of molecular sciences2025

Salivary Proteome Profile of Xerostomic Patients Reveals Pathway Dysregulation Related to Neurodegenerative Diseases: A Pilot Study.

Abhijeet A Henry, Micaela F Beckman, Thomas S Fry, Michael T Brennan, Farah Bahrani Mougeot, Jean-Luc C Mougeot

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abhijeet A HenryTranslational Research Laboratories, Cannon Research Center, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Micaela F BeckmanTranslational Research Laboratories, Cannon Research Center, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Thomas S FryDepartment of Oral Medicine/Oral and Maxillofacial Surgery, Wake Forest University School of Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Michael T BrennanDepartment of Oral Medicine/Oral and Maxillofacial Surgery, Wake Forest University School of Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Farah Bahrani MougeotTranslational Research Laboratories, Cannon Research Center, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0000-0002-8903-333X
Jean-Luc C MougeotTranslational Research Laboratories, Cannon Research Center, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0000-0002-8953-1769

Funding

Atrium Health Foundation Research Fund Internal Funding
6 · The paper itself

Abstract

Xerostomia, the subjective complaint of a dry mouth, is frequently associated with salivary flow reduction and/or salivary gland hypofunction. This condition significantly impacts an individual's quality of life and oral health, including difficulties in speaking, chewing, and swallowing. Xerostomia may be caused by autoimmune diseases, xerogenic medications, and radiation therapy. Our objective was to identify differentially expressed proteins in the saliva of patients with medication and autoimmune disease-associated xerostomia compared to non-xerostomic control subjects. Two groups of individuals (N = 45 total) were recruited: non-xerostomic subjects (NX-group;

Indexed as

Neurodegenerative DiseasesProteomeSalivaSalivary Proteins and PeptidesXerostomiaAdultAgedFemaleHumansMaleMiddle AgedPilot ProjectsProtein Interaction MapsProteomicsSalivary GlandsProteomeSalivary Proteins and Peptidesdry mouthneurodegenerative diseasesproteomicssalivasalivary hypofunctionxerostomia

Identifiers

PMID40806170
PMCPMC12346731

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.