Evidence map›Paper›PMID 40806165›Full record

ArticleInternational journal of molecular sciences2025

Circulating Biomarkers as Potential Risk Factors for Inguinal Hernia.

Enke Baldini, Salvatore Sorrenti, Eleonora Lori, Luigi Palla, Silvia Cardarelli, Daniele Pironi, Domenico Tripodi, Antonio Pavan, Azis Fakeri, Vilma Cobo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Enke BaldiniDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-8999-1386
Salvatore SorrentiDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0427-6648
Eleonora LoriDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1943-4952
Luigi PallaDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6944-1750
Silvia CardarelliDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.
Daniele PironiDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1545-0779
Domenico TripodiDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-4190-8168
Antonio PavanImmunohaematology and Transfusion Center, Umberto I General Hospital, "Sapienza" University of Rome, 00185 Rome, Italy.
Azis FakeriImmunohaematology and Transfusion Center, Umberto I General Hospital, "Sapienza" University of Rome, 00185 Rome, Italy.
Vilma CoboImmunohaematology and Transfusion Center, Umberto I General Hospital, "Sapienza" University of Rome, 00185 Rome, Italy.
Chiara PellegriniDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.
Priscilla NardiDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.
Valerio RinaldiDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0009-0005-1778-9399
Salvatore UlisseDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-7573-0759
Piergaspare PalumboDepartment of Surgery, "Sapienza" University of Rome, 00185 Rome, Italy.

Funding

Sapienza University of Rome RM12117A87C69711
6 · The paper itself

Abstract

Independent studies reported metabolic alterations in connective tissues of hernia patients, especially involving collagen fibers, compared to healthy controls. In the present work, we evaluated plasma concentrations of metalloproteinases (MMPs) and lysyl oxidase (LOX), enzymes involved in collagen metabolism, and peptides produced during collagen biosynthesis (PINP, PIIINP, and PIVNP) as potential biomarkers for the estimation of hernia risk. Zymography and ELISA assays were performed with plasma samples of 51 patients with primary or recurrent inguinal hernia and 42 healthy controls. A reduction in PINP (

Indexed as

BiomarkersHernia, InguinalAdultAgedCase-Control StudiesFemaleHumansMaleMatrix Metalloproteinase 2Middle AgedPeptide FragmentsProcollagenProtein-Lysine 6-OxidaseRisk FactorsROC CurveBiomarkersMatrix Metalloproteinase 2Peptide FragmentsProcollagenprocollagen Type III-N-terminal peptideProtein-Lysine 6-Oxidasecollageninguinal hernialysyl oxidasemetalloproteinasesN-terminal propeptides of type I (PINP) and type III (PIIINP) procollagens

Identifiers

PMID40806165
PMCPMC12346474

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.