Evidence map›Paper›PMID 40806025›Full record

ArticleNutrients2025

A 3-Week Inpatient Rehabilitation Programme Improves Body Composition in People with Cystic Fibrosis with and Without Elexacaftor/Tezacaftor/Ivacaftor Therapy.

Jana Koop, Wolfgang Gruber, Franziska A Hägele, Kristina Norman, Catrin Herpich, Stefan Dewey, Christian Falkenberg, Olaf Schnabel, Burkhard Weisser, Mario Hasler and 1 more

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In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jana KoopInstitute of Human Nutrition and Food Science, Kiel University, Düsternbrooker Weg 17, 24105 Kiel, Germany.ORCID 0000-0002-8074-731X
Wolfgang GruberInstitute of Human Nutrition and Food Science, Kiel University, Düsternbrooker Weg 17, 24105 Kiel, Germany.ORCID 0000-0003-2186-9269
Franziska A HägeleInstitute of Human Nutrition and Food Science, Kiel University, Düsternbrooker Weg 17, 24105 Kiel, Germany.
Kristina NormanDepartment of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Catrin HerpichDepartment of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Stefan DeweyStrandklinik St. Peter-Ording, Fritz-Wischer-Straße 3, 25826 St. Peter-Ording, Germany.
Christian FalkenbergFachklinik Satteldüne DRV Nord, Tanenwai 32, 25946 Nebel, Germany.
Olaf SchnabelFachklinik Satteldüne DRV Nord, Tanenwai 32, 25946 Nebel, Germany.
Burkhard WeisserDepartment of Sportsmedicine, Kiel University, Olshausenstrasse 74, 24118 Kiel, Germany.
Mario HaslerApplied Statistics, Kiel University, Hermann-Rodewald-Strasse 9, 24098 Kiel, Germany.ORCID 0000-0002-4781-2386
Anja Bosy-WestphalInstitute of Human Nutrition and Food Science, Kiel University, Düsternbrooker Weg 17, 24105 Kiel, Germany.ORCID 0000-0002-8318-9448

Funding

Deutsche Rentenversicherung Nord RSS 2.10.17.0Mukoviszidose Selbsthilfe e.V noneSchleswig-Holsteinische Vereinigung zur Bekämpfung der Tuberkulose und der Lungenkrankheiten e.V. none
6 · The paper itself

Abstract

backgroundThe introduction of cystic fibrosis transmembrane conductance regulator modulators, especially the triple therapy elexacaftor, tezacaftor, ivacaftor (ETI), has improved outcomes in people with cystic fibrosis (pwCF), reducing underweight but increasing overweight rates.

objectivesThis study investigates the effect of ETI on appetite control, body composition, and energy balance during a 3-week inpatient rehabilitation programme with regular exercise.

methodsIn 54 pwCF (38 on ETI, 16 without ETI), changes in body composition (fat mass index, FMI; fat-free mass index, FFMI) and energy balance (calculated from body composition changes) were assessed. Appetite control was evaluated via plasma peptide YY (PYY) levels and post-exercise meal energy intake.

resultsThe programme significantly increased BMI (+0.3 ± 0.1 kg/m

conclusionsA 3-week inpatient rehabilitation programme improved body composition in pwCF, without resulting in a more positive energy balance with ETI therapy. This is due to a higher prevalence of pancreatic insufficiency in this group.

Indexed as

AminophenolsBenzodioxolesBody CompositionCystic FibrosisIndolesPyrazolesPyridinesPyrrolidinesQuinolonesAdolescentAdultBody Mass IndexDrug CombinationsEnergy IntakeEnergy MetabolismExerciseAminophenolsBenzodioxolesDrug CombinationselexacaftorIndolesivacaftorPyrazolesPyridinesPyrrolidinesQuinolonestezacaftorappetite controlbody compositionCF rehabilitationElexacaftor/Tezacaftor/Ivacaftorenergy balancetriple CFTR modulators

Identifiers

PMID40806025
PMCPMC12348923

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.