Evidence map›Paper›PMID 40806002›Full record

ReviewNutrients2025

Potential Health Benefits of Dietary Tree Nut and Peanut Enrichment in Kidney Transplant Recipients-An In-Depth Narrative Review and Considerations for Future Research.

Daan Kremer, Fabian A Vogelpohl, Yvonne van der Veen, Caecilia S E Doorenbos, Manuela Yepes-Calderón, Tim J Knobbe, Adrian Post, Eva Corpeleijn, Gerjan Navis, Stefan P Berger and 1 more

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daan KremerDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-0011-115X
Fabian A VogelpohlDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-2702-9228
Yvonne van der VeenDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.
Caecilia S E DoorenbosDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.
Manuela Yepes-CalderónDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.
Tim J KnobbeDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-3246-3192
Adrian PostDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-8645-1627
Eva CorpeleijnDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Gerjan NavisDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.
Stefan P BergerDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-2228-4676
Stephan J L BakkerDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Post Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-3356-6791

Funding

Top Sector Life Sciences & Health PPP2023-006
6 · The paper itself

Abstract

Kidney transplant recipients face a substantial burden of premature mortality and morbidity, primarily due to persistent inflammation, cardiovascular risk, and nutritional deficiencies. Traditional nutritional interventions in this population have either focused on supplementing individual nutrients-often with limited efficacy-or required comprehensive dietary overhauls that compromise patient adherence. In this narrative review, we explore the rationale for dietary nut enrichment as a feasible, multi-nutrient strategy tailored to the needs of kidney transplant recipients. Nuts, including peanuts and tree nuts with no added salt, sugar, or oil, are rich in beneficial fats, proteins, vitamins, minerals, and bioactive compounds. We summarize the multiple post-transplant challenges-including obesity, sarcopenia, dyslipidemia, hypertension, immunological dysfunction, and chronic inflammation-and discuss how nut consumption may mitigate these issues through mechanisms involving improved micro-nutrient intake (e.g., magnesium, potassium, selenium), lipid profile modulation, endothelial function, immune support, and gut microbiota health. Additionally, we highlight the scarcity of randomized controlled trials in high-risk populations such as kidney transplant recipients and make the case for studying this group as a model for investigating the clinical efficacy of nuts as a nutritional intervention. We also consider practical aspects for future clinical trials, including the choice of study population, intervention design, duration, nut type, dosage, and primary outcome measures such as systemic inflammation. Finally, potential risks such as nut allergies and oxalate or mycotoxin exposure are addressed. Altogether, this review proposes dietary nut enrichment as a promising, simple, and sustainable multi-nutrient approach to support cardiometabolic and immune health in kidney transplant recipients, warranting formal investigation in clinical trials.

Indexed as

ArachisDietKidney TransplantationNutsTransplant RecipientsHumansagingdietary interventionfibrosisinflammationkidney transplant recipientsmicro-nutrientsnutsoxidative stressvery long-chain saturated fatty acids

Identifiers

PMID40806002
PMCPMC12348535

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.