Evidence map›Paper›PMID 40805278›Full record

ArticleCancers2025

The Fanconi Anemia Pathway Inhibits mTOR Signaling and Prevents Accelerated Translation in Head and Neck Cancer Cells.

Bianca Ruffolo, Sara Vicente-Muñoz, Khyati Y Mehta, Cosette M Rivera-Cruz, Xueheng Zhao, Lindsey Romick, Kenneth D R Setchell, Adam Lane, Susanne I Wells

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bianca RuffoloDivision of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Sara Vicente-MuñozDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-4454-8900
Khyati Y MehtaDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Cosette M Rivera-CruzDivision of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0001-5487-0106
Xueheng ZhaoDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.ORCID 0000-0002-4156-3294
Lindsey RomickDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0002-7252-1193
Kenneth D R SetchellDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Adam LaneDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Susanne I WellsDivision of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Funding

ENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9M
Global Lipidomics Analysis Techniques for Novel Biomarker Discovery of Environmental EnteropathyF31DK131885 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI MEHTA, KHYATI · 2022 to 2023
$62k
NIDDK NIH HHS F31 DK131885NIEHS NIH HHS T32 ES007250NIH HHS 1F30CA281167-01A1NIH HHS 1F31DK131885-01A1NIH HHS 5R01CA223790-05NIH HHS 5T32ES007250-34
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cancer metabolismFanconi Anemiahead and neck cancermTOR

Identifiers

PMID40805278
PMCPMC12346401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.