Evidence map›Paper›PMID 40805269›Full record

ArticleCancers2025

Apalutamide Monotherapy in Metastatic Hormone-Sensitive Prostate Cancer: A Viable Alternative to First-Generation Anti-Androgen Agents to Avoid the Flare Phenomenon and an Effective Treatment for Achieving Early PSA Response.

Gaetano Facchini, Andrea D'Arienzo, Antonella Nicastro, Fabiano Flauto, Michela Izzo, Liliana Montella, Filippo Riccardo, Giovanni Maria Fusco, Francesco Trama, Giovanni Di Lauro and 16 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Gaetano FacchiniOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.ORCID 0000-0002-7430-001X
Andrea D'ArienzoOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.ORCID 0009-0002-6435-8522
Antonella NicastroOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.ORCID 0009-0004-8598-0323
Fabiano FlautoClinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.
Michela IzzoOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Liliana MontellaOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.ORCID 0000-0002-6397-086X
Filippo RiccardoUrology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Giovanni Maria FuscoUrology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Francesco TramaUrology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Giovanni Di LauroUrology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Giuseppe Di CostanzoRadiology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Anna Giacoma TucciRadiology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Francesca IasielloRadiology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Lorena Di LorenzoClinical Pathology Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Salvatore MaddalunoClinical Pathology Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Carmela LiguoriOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Rita Assante di CupilloOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Paola CoppolaOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Angela MinissaleOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Maria Teresa Di NardoOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
Luigi FormisanoClinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-7205-5105
Erika MartinelliDepartment of Precision Medicine, The University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Giuliana CiappinaDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0813-3126
Salvatore PiscontiOncology Unit, Ospedale San Giuseppe Moscati, Statte, 74010 Taranto, Italy.
Massimiliano BerrettaDivision of Oncology, Azienda Ospedaliera Universitaria "Gaetano Martino" Hospital, 98124 Messina, Italy.ORCID 0000-0002-9837-9148
Chiara BarracoOncology Complex Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.ORCID 0009-0004-9244-8263

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

androgen deprivation therapyandrogen receptor targeted agentsapalutamideflare phenomenonmetastatic hormone-sensitive prostate cancerreal-world analysestreatment

Identifiers

PMID40805269
PMCPMC12346201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.