Evidence map›Paper›PMID 40805157›Full record

ReviewCancers2025

Targeting Wnt Signaling in Acute Lymphoblastic Leukemia.

Samantha Hurwitz, Ki Jun Lee, Tatiana Fourfouris, Irene Choi, Krishan Parikh, Rachel Friedmann, Maiah Zarrabi, Yong-Mi Kim

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samantha HurwitzChildren's Hospital Los Angeles, Division of Hematology and Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.ORCID 0000-0002-6580-3379
Ki Jun LeeChildren's Hospital Los Angeles, Division of Hematology and Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.ORCID 0009-0005-4740-9801
Tatiana FourfourisChildren's Hospital Los Angeles, Division of Hematology and Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.ORCID 0009-0004-2057-4148
Irene ChoiChildren's Hospital Los Angeles, Division of Hematology and Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Krishan ParikhChildren's Hospital Los Angeles, Division of Hematology and Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Rachel FriedmannChildren's Hospital Los Angeles, Division of Hematology and Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Maiah ZarrabiChildren's Hospital Los Angeles, Division of Hematology and Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.ORCID 0000-0001-5716-4215
Yong-Mi KimChildren's Hospital Los Angeles, Division of Hematology and Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.ORCID 0000-0003-3793-6438

Funding

Saban Research Institute 001
6 · The paper itself

Abstract

The Wnt signaling pathway plays a critical role in regulating normal hematopoiesis and immune cell development. However, its dysregulation has emerged as a key driver of leukemogenesis. Leukemic stem cells exploit aberrant Wnt signaling to sustain self-renewal, evade apoptosis, and promote unchecked proliferation. In this review, we highlight the dual roles of canonical and non-canonical Wnt pathways in acute leukemia, emphasizing their distinct and overlapping contributions to disease progression. We also evaluate current preclinical and clinical strategies targeting Wnt signaling, identifying both promising advances and persistent obstacles to therapeutic translation. By elucidating the molecular mechanisms underlying Wnt pathway dysregulation in leukemic cells, this review underscores the potential of Wnt-directed therapies as a novel class of interventions to improve outcomes for patients with acute leukemia.

Indexed as

acute lymphoblastic leukemiaWnt inhibitorsWnt signaling

Identifiers

PMID40805157
PMCPMC12345650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.