ArticleAnimals : an open access journal from MDPI2025
Exploratory Meta-Analysis of the Effect of Malic Acid or Malate Addition on Ruminal Parameters, Nutrient Digestibility, and Blood Characteristics of Cattle.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Rumen-Plasma-Milk Metabolomics Profiling Revealed Metabolic Alterations Associated with Milk Fat Synthesis in Chinese Holstein Cows.Animals : an open access journal from MDPI · 2026Article
- Effects of Initiation Age of Starter Feeding on Growth Performance, Immunity and Antioxidant Capacity, Gastrointestinal Development, and Microbial Communities in Suckling Lambs.Microorganisms · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine, through meta-analysis, the effects of malic acid/malate addition on ruminal and blood parameters and diet digestibility in cattle. The literature search was conducted in Web of Science, Science Direct, and Google Scholar using the terms "organic acids", "malic acid", "malate", and "bovine". The database was composed of papers published between 1980 and 2023. The average effect of malate/malic acid inclusion was calculated using the "DerSimonian and Laird" random effects model. Meta-regression and subgroup analyses were conducted to explore sources of heterogeneity. Overall, malic acid (MAC) addition did not significantly affect rumen pH (ES = 0.310,
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Registered trials
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