Evidence map›Paper›PMID 40804776›Full record

ArticleMedical physics2025

Magnetic Resonance Imaging monitoring of histotripsy effects in agar phantom.

Anastasia Antoniou, Nikolas Evripidou, Leonidas Georgiou, Antonis Christofi, Jufeng Zhao, Liyang Yu, Wenjun Li, George C Kagadis, Christakis Damianou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anastasia AntoniouDepartment of Electrical Engineering, Computer Engineering, and Informatics, Cyprus University of Technology, Limassol, Cyprus.
Nikolas EvripidouDepartment of Electrical Engineering, Computer Engineering, and Informatics, Cyprus University of Technology, Limassol, Cyprus.
Leonidas GeorgiouDiagnostic and Interventional Radiology Department, German Medical Institute, Limassol, Cyprus.
Antonis ChristofiDiagnostic and Interventional Radiology Department, German Medical Institute, Limassol, Cyprus.
Jufeng ZhaoDepartment of Electronics and Information Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang, China.
Liyang YuDepartment of Electronics and Information Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang, China.
Wenjun LiDepartment of Electronics and Information Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang, China.
George C Kagadis3DMI Research Group, Department of Medical Physics, School of Medicine, University of Patras, Rion-Patras, Greece.
Christakis DamianouDepartment of Electrical Engineering, Computer Engineering, and Informatics, Cyprus University of Technology, Limassol, Cyprus.

Funding

BRAINSONIC ENTERPRISES/0223/Sub-Call1/0057Recovery and Resilience FacilityResearch and Innovation Foundation of Cyprus
6 · The paper itself

Abstract

backgroundWhile the technical aspects of histotripsy have seen significant advancements, research on Magnetic Resonance Imaging (MRI) monitoring remains limited. PURPOSE: This preliminary study explored the use of conventional T2-Weighted (T2-W) Turbo Spin Echo (TSE) imaging to monitor histotripsy lesions in a pure agar gel, as a potential research tool for MRI-guided histotripsy (MRgHt).

methodsHistotripsy experiments were conducted in a 3T MRI scanner using a 2% weight per volume agar solution in water. Pulsed Focused Ultrasound (FUS) was applied at a duty factor of 2%, with a pulse repetition period of 1s, delivering up to 2000 pulses. T2-W TSE imaging was employed for intra-procedural monitoring with 10s updates and post-sonication assessment, with the first prioritizing rapid acquisition and the second focusing on resolution. Supplementary, MR thermometry tracked temperature variations throughout the procedure.

resultsDynamic T2-W TSE imaging provided insights into the progress of phantom disruption. Mild thermal effects served as early signs of phantom response, as mechanical effects required more time to manifest. Typical histotripsy lesion characteristics were observed, including a hyperintense core with an elongated shape and a thin hypointense border. The developed temperatures remained well below hyperthermia levels, reaching a maximum of 34°C.

conclusionsThe presented methodology, utilizing a pure agar gel within a simple, versatile setup alongside conventional T2-W TSE imaging, holds promise for advancing MRgHt research.

Indexed as

AgarHigh-Intensity Focused Ultrasound AblationMagnetic Resonance ImagingPhantoms, ImagingTemperatureAgaragar gelhistotripsylesion monitoringMRIT2‐W

Identifiers

PMID40804776
PMCPMC12350826

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.