Evidence map›Paper›PMID 40804711›Full record

ReviewWiley interdisciplinary reviews. RNA

Emerging Roles of Biomolecular Condensates in Pre-mRNA 3' End Processing.

Yoseop Yoon, Liang Liu, Cailyx Quan, Yongsheng Shi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Wiley interdisciplinary reviews. RNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoseop YoonDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0002-6062-0979
Liang LiuDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0002-9655-204X
Cailyx QuanDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California, USA.
Yongsheng ShiDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0003-2967-1230

Funding

mRNA alternative polyadenylation in B cell developmentR01AI170840 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Roger Sciammas, Yongsheng Shi · 2022 to 2026
$4.1M
Mechanisms and regulation of mRNA 3' processingR35GM149294 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Yongsheng Shi · 2023 to 2026
$2.1M
Decode polyadenylation in health and diseaseR01CA297834 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Yongsheng Shi · 2025 to 2026
$1.3M
National Institute of Allergy and Infectious Diseases R01AI170840NCI NIH HHS R01 CA297834NCI NIH HHS R01CA297834NIAID NIH HHS R01 AI170840NIGMS NIH HHS R35 GM149294NIGMS NIH HHS R35GM149294
6 · The paper itself

Abstract

Biomolecular condensates are membraneless assemblies of proteins and nucleic acids, often formed through liquid-liquid phase separation. They selectively concentrate specific biomolecules and play essential roles in diverse cellular processes and diseases. This review discusses the emerging roles of biomolecular condensates in pre-mRNA 3' end processing, a critical step in mRNA biogenesis. 3' end processing factors are enriched in intrinsically disordered regions and undergo phase separation to form condensates that, in turn, fine-tune the efficiency and specificity of 3' end processing. Additionally, we describe how distinct 3' end processing pathways are spatially and functionally compartmentalized within nuclear biomolecular condensates, such as nuclear speckles and histone locus bodies. Finally, we propose that 3' end processing represents a promising experimental system to investigate fundamental principles underlying biomolecular condensate formation and function. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.

Indexed as

Biomolecular CondensatesRNA 3' End ProcessingRNA, MessengerRNA PrecursorsAnimalsHumansIntrinsically Disordered ProteinsNuclear SpecklesPhase SeparationIntrinsically Disordered ProteinsRNA, MessengerRNA Precursorsbiomolecular condensatemembraneless organellemRNA 3′ processingnuclear specklepolyadenylation

Identifiers

PMID40804711
PMCPMC12441778

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.