Evidence map›Paper›PMID 40804681›Full record

ArticleBiology direct2025

High oxidative phosphorylation represented by UQCRFS1 marks CD8 + tumor-infiltrating lymphocytes exhaustion in diffuse large B-cell lymphoma.

Yiming Yang, Yaqi Shu, Zujun Qin, Yi Zeng, Kexin Chen, Xin Liu, Shunhai Jian, Qiqi Zhu

Abstract read
In one paragraph

Article in Biology direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Integrative Multiomics and Single-Cell Profiling Identify TNFRSF1AComputational and structural biotechnology journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiming Yang *Department of Pathology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, Sichuan, 637000, China.
Yaqi Shu *Department of Pathology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, Sichuan, 637000, China.
Zujun QinDepartment of Pathology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, Sichuan, 637000, China.
Yi ZengDepartment of Pathology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, Sichuan, 637000, China.
Kexin ChenDepartment of Pathology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, Sichuan, 637000, China.
Xin LiuDepartment of Pathology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, Sichuan, 637000, China.
Shunhai JianDepartment of Pathology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, Sichuan, 637000, China.
Qiqi ZhuDepartment of Pathology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, Sichuan, 637000, China. 359059927@qq.com.

Funding

Scientific Research and Development Fund Project, North Sichuan Medical College CBY23-QNA35Sichuan Science and Technology Program 2025ZNSFSC1697
6 · The paper itself

Abstract

backgroundMetabolic alterations are closely associated with the exhaustion and immune deficiency of CD8

methodsThe metabolic alterations in exhausted CD8

resultsOur study illustrated the metabolic heterogeneity in CD8

conclusionsOur study highlights the importance of OXPHOS activity in CD8

Indexed as

CD8-Positive T-LymphocytesLymphocytes, Tumor-InfiltratingLymphoma, Large B-Cell, DiffuseOxidative PhosphorylationAdultAgedFemaleHumansMaleMiddle AgedTumor MicroenvironmentCD8+tumor-infiltrating lymphocytesClinicopathological analysisDiffuse large B-cell lymphomaExhaustionImmunotherapyMetabolismOxidative phosphorylationPrognosis

Identifiers

PMID40804681
PMCPMC12345122

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.