ArticleNutrition & metabolism2025
Muscle-building interventions improve glucose metabolism in elderly type 2 diabetic patients with sarcopenic obesity.
Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimizing health outcomes for older adults with sarcopenic obesity: a scoping review of nutrition, exercise and combined interventions.Frontiers in nutrition · 2026Pooled it
- Beyond BMI: an interpretable integrated body composition index from low-dose chest CT for all-cause mortality risk stratification: a multicentre study.medRxiv : the preprint server for health sciences · 2026Article
- Beyond muscle mass: methodological rigor and clinical translation in interventions for sarcopenic obesity with type 2 diabetes.Nutrition & metabolism · 2026Article
- Water Extract of Polygonati Rhizoma Ameliorates Obesity-Related Skeletal Muscle Atrophy in Mice and C2C12 Myotubes.Nutrients · 2026Article
- Functional training for sarcopenia in older adults: mechanisms, benefits, and clinical implications.Frontiers in public health · 2026Review
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Authors and funding
13 authors.
Funding
Abstract
backgroundAmong all the elderly patients with type 2 diabetes mellitus (T2DM) of different body compositions, patients with sarcopenic obesity exhibited the most severe degree of insulin resistance despite possessing a normal body weight. It is well-established that interventions encompassing resistance training alone or in combination with whey protein supplementation, referred to hereafter as muscle-building interventions, are effective for increasing muscle mass and function in the elderly population. However, the impact of these muscle-building interventions on glucose metabolism in elderly T2DM patients with sarcopenic obesity remains unclear. The objective of this study was to elucidate the effect of muscle-building interventions on blood glucose and insulin resistance in elderly T2DM patients with sarcopenic obesity.
methodsThe muscle-building interventions in this study included resistance training alone and resistance training combined with whey protein supplementation. In this randomized controlled trial, elderly T2DM patients with sarcopenic obesity were divided into three distinct groups: the control group, the resistance training group, and the resistance training combined with whey protein supplement group. The muscle-building interventions were conducted for 12 weeks.
resultsImplementing muscle-building interventions showed significant improvements in glycemic indices (HbA1c, OGTT 2-hour plasma glucose) and insulin resistance levels (HOMA-IR, Gutt index) for elderly T2DM patients with sarcopenic obesity. These muscle-building interventions enhanced muscle functional indices (handgrip strength, 5-time chair stand test). The combination of resistance training with whey protein supplementation did not significantly enhance the favorable effects on glucose metabolism compared to resistance exercise alone. Correlation analyses revealed that improvements in muscle strength were significantly associated with enhancements in glucose metabolism.
conclusionsIn elderly T2DM patients with sarcopenic obesity, muscle-building interventions (particularly resistance exercise) have been shown to significantly improve blood glucose control and insulin resistance.
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