Evidence map›Paper›PMID 40804663›Full record

ArticleBMC infectious diseases2025

Fibulin2 is a good diagnostic and prognostic indicator for sepsis.

Xiaowen Gao, Shidan Li, Jinze Wu, Yiyun Feng, Wei Xing, Xiaoming Li, Yimin Du, Debin Guo, Honghao Xu, Dongqin Tang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Xiaowen Gao *War Trauma Medical Center, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Shidan Li *War Trauma Medical Center, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Jinze WuWar Trauma Medical Center, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Yiyun FengNanjing No.29 High School, Nanjing, 210019, China.
Wei XingResearch Institute of Surgery, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Xiaoming LiResearch Institute of Surgery, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Yimin DuDepartment of Orthopaedics, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Debin GuoDepartment of Emergency, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Honghao XuDepartment of Emergency, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Dongqin TangDepartment of Emergency, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Shaochuan WangWar Trauma Medical Center, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Youbin LiWar Trauma Medical Center, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Jing YangDepartment of Emergency, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Jianfei MaDepartment of Emergency, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Yamei ZhangDepartment of Emergency, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Lei LiResearch Institute of Surgery, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Jun FeiState Key Laboratory of Trauma, Burns and Combined Injuries, Army Medical Center, Third Military Medical University, Chongqing, 400042, China. feijundoctor@sohu.com.

Funding

Chongqing Science and Technology Committee Joint Traditional Chinese Medicine Research Project 2023DBXM010National Natural Science Foundation of China 82302435Project of the State Key Laboratory of Trauma, Burn and Combined Injury SKLZZ202201Training Plan of Talent Innovation Ability in Army Medical Center ZXYZZKY01
6 · The paper itself

Abstract

backgroundSepsis is a life-threatening syndrome characterized by multiple organ dysfunction resulting from a maladjusted host response to infection. It remains a leading cause of morbidity and mortality worldwide. Early intervention for sepsis improves clinical outcomes. This study aimed to develop a diagnostic and prognostic indicator at the onset of sepsis.

methodsFrom January 2021 to December 2023, patients in the emergency department (ED) were evaluated for the use of Fibulin2 as a diagnostic and prognostic indicator for sepsis. The levels of Fibulin2 in plasma were detected via enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) curves were generated to assess the performance of Fibulin2 for predicting sepsis.

resultsThe level of serum Fibulin2 was significantly higher in patients with sepsis than in controls, and Fibulin2 had diagnostic value for sepsis and performed better than C-reactive protein (CRP), procalcitonin (PCT), the white blood cell count (WBC), the neutrophil ratio (NEU%), and D-dimer. Overall, Fibulin2 was upregulated in patients with septic shock compared with septic patients without shock, and Fibulin2 can be used to diagnose septic shock. Moreover, Fibulin2 was increased in patients who died at 28 days of sepsis and had the potential to predict 28-day mortality.

conclusionFibulin2 may serve as a diagnostic and prognostic biomarker for sepsis in the ED.

Indexed as

Calcium-Binding ProteinsSepsisAdultAgedAged, 80 and overBiomarkersC-Reactive ProteinEmergency Service, HospitalExtracellular Matrix ProteinsFemaleHumansMaleMiddle AgedProcalcitoninPrognosisROC CurveBiomarkersCalcium-Binding ProteinsC-Reactive ProteinExtracellular Matrix Proteinsfibulin 2ProcalcitoninDiagnosisFibulin2Roc curveSepsis

Identifiers

PMID40804663
PMCPMC12344871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.