Evidence map›Paper›PMID 40804634›Full record

ReviewJournal of translational medicine2025

From network biology to immunity: potential longitudinal biomarkers for targeting the network topology of the HIV reservoir.

Heng-Chang Chen

Abstract readReview
In one paragraph

Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Heng-Chang ChenQuantitative Virology Research Group, Population Diagnostics Center, Łukasiewicz Research Network - PORT Polish Center for Technology Development, Stablowicka 147, 54-066, Wrocław, Poland. heng-chang.chen@port.lukasiewicz.gov.pl.ORCID 0000-0003-2117-7385

Funding

Narodowe Centrum Nauki UMO-2022/46/E/NZ6/00022
6 · The paper itself

Abstract

In the "omics" era, studies often utilize large-scale datasets, eliciting the overall functional machinery of a network's organization. In this context, determining how to read the enormous number of interactions in a network is imperative to comprehend its functional organization. Topology is the principal attribute of any network; as such, topological properties help to elucidate the roles of entities and represent a network's behavior. In this review, I showcase the foundational concepts involved in graph theory, which form the basis of network biology, and exemplify the application of this conceptual framework to bridge the connection between the task-evoked functional genome network of the HIV reservoir. Furthermore, I point out potential longitudinal biomarkers identified using network-based analysis and systematically compare them with other potential biomarkers identified based on experimental research with longitudinal clinical samples.

Indexed as

BiomarkersHIVHIV InfectionsImmunityHumansLongitudinal StudiesBiomarkersBiological networksDeep learningElite controllersGraph theoryHIV reservoirImmunologic signaturesLongitudinal biomarkersNetwork analysisNetwork topology

Identifiers

PMID40804634
PMCPMC12351972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.