Evidence map›Paper›PMID 40804626›Full record

ReviewCardiovascular diabetology2025

Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy.

Yingjie Feng, Yajing Wang, Yifan Deng, Peifen Li, Penghua Fang, Zhenwen Zhang

Abstract readReview
In one paragraph

Review in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yingjie Feng *Department of Endocrinology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Yajing Wang *Department of Endocrinology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Yifan DengDepartment of Cardiovascular, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.
Peifen LiMedical College, Yangzhou University, Yangzhou, 225001, China.
Penghua FangKey Laboratory for Metabolic Diseases in Chinese Medicine, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China. hlcollegesci@sina.cn.
Zhenwen ZhangDepartment of Endocrinology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China. zwzhang@yzu.edu.cn.

Funding

National Natural Scientific Fund of China 82374100
6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM) is a prevalent complication in diabetic patients, and its pathogenic mechanism involves multiple endocrine and metabolic factors, with dyslipidemia playing a pivotal role in the pathogenesis of the disease. Recent studies have highlighted the importance of peptides in energy metabolism and their potential effect on the onset and development of DCM by affecting the function of perivascular adipose tissue (PVAT). The present review aims to examine the effect of these peptides on perivascular adipose tissue and myocardial metabolism during the pathogenesis of DCM, focusing on the role of peptides distributed in perivascular adipose tissue in cardioprotection and their underlying mechanisms of action. In addition, we will explore future research directions and potential clinical applications of these peptides in the treatment of DCM.

Indexed as

AdipocytesAdipose TissueDiabetic CardiomyopathiesEnergy MetabolismMyocardiumAnimalsHumansSignal TransductionDiabetic cardiomyopathyPeptidesPerivascular adipose tissue

Identifiers

PMID40804626
PMCPMC12344842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.