SynthesisBMC gastroenterology2025
Impact of microplastics on the human gut microbiome: a systematic review of microbial composition, diversity, and metabolic disruptions.
Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microplastics and nanoplastics in inflammatory bowel disease: Mechanistic plausibility, human evidence and future research priorities.World journal of gastrointestinal pathophysiology · 2026Review
- Abdominal Bloating in the Modern Era: Pathophysiological Mechanisms and Environmental Contributors.Biomolecules · 2026Review
- Micro- and Nanoplastics as Environmental Stressors: Mechanistic Links Among Gut Dysbiosis, Inflammation, and Systemic Health Effects.Journal of xenobiotics · 2026Review
- Microplastics and nanoplastics in human toxicity: ROS-mediated mechanisms, cellular damage and systemic effects.Molecular biology reports · 2026Review
- Biofilms on microplastics across ecological systems: Formation mechanisms, community composition, environmental impacts, and ecotoxicity.World journal of microbiology & biotechnology · 2026Review
- Article
- Spore-Forming Probiotic-Embedded Biomaterials for Targeted Gut Microplastic Biodegradation.ACS pharmacology & translational science · 2026Review
- Microplastics in early-onset carcinogenesis.Carcinogenesis · 2026Review
- Environmental Exposure to Micro- and Nanoplastics: Linking Cardiovascular Disease and Cancer Through Shared Biological Pathways-A Critical Review.Antioxidants (Basel, Switzerland) · 2026Review
- Gut-Microbial Responses to Acute Polyester Microplastic Exposure in Zebrafish: Dysbiosis, Opportunistic Bacteria, and Functional Impact.International journal of molecular sciences · 2026Article
- Clinical Significance of Exposure to Microplastics and the Risk of Diabetes Mellitus in Humans: A Systematic Review.Cureus · 2026Review
- Ingested microplastics and gastrointestinal health: a comprehensive review of their role in gut inflammation and dysbiosis.Annals of medicine and surgery (2012) · 2026Article
- Exposure to known and emerging groundwater contaminants significantly alters poultry microbiome and metabolome.Applied and environmental microbiology · 2026Article
- Review
- Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut-skin axis.Journal of translational medicine · 2026Review
- Maternal Exposure to Microplastics and High-Fructose Diet Induces Offspring Hypertension via Disruption of HAntioxidants (Basel, Switzerland) · 2026Article
- From Kitchen to Cell: A Critical Review of Microplastic Release from Consumer Products and Its Health Implications.Toxics · 2026Review
- Pathogenesis of Micro/Nanoplastics in Mammalian Systems: Gut to Systemic Multi-Organ Dysfunction.Research (Washington, D.C.) · 2026Review
- From farm to fork: Microplastic contamination in the meat and dairy supply chain.Current research in food science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Global plastic waste production remains a critical environmental issue. Microplastics (MPs), plastic particles less than 5 mm, are now pervasive across ecosystems. Humans are exposed to MPs via ingestion, inhalation, and dermal contact raising concerns about their health impacts. This systematic review investigates the influence of MPs on the human gut microbiome, focusing on changes in microbial composition, diversity, and metabolic pathways based on 12 studies identified through Scopus and PubMed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Findings show that exposure to MPs such as polyethylene (PE), polystyrene (PS), polyethylene terephthalate (PET), polyvinyl chloride (PVC), and polylactic acid (PLA), induces gut dysbiosis, marked by a loss of beneficial genera, and enrichment of pathogenic species. MPs also impair short-chain fatty acid (SCFA) production, alter metabolic functions, and modulate immune pathways, contributing to intestinal diseases, metabolic syndrome, and chronic inflammation. The extent of disruption is influenced by MP-specific properties such as type, size, and concentration. These results suggest that MPs are emerging environmental risk factors with tangible implications for human health. To fully understand the health concerns associated with MPs long-term, human-relevant studies with standardized methodologies are urgently needed to define safe exposure levels and guide policies aimed at reducing MP-related health risks.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.