Evidence map›Paper›PMID 40804477›Full record

ArticleExperimental & molecular medicine2025

Mx1-labeled pulp progenitor cells are the main contributors of odontoblast and dentin regeneration in murine molars.

Dongwook Yang, Youngjae Jeong, Laura Ortinau, Jea Giezl Solidum, Dongsu Park

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

  • Update of
    2024
5 · Who and what money

Authors and funding

5 authors.

Dongwook YangDepartment of Molecular Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Youngjae JeongDepartment of Molecular Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Laura OrtinauDepartment of Molecular Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Jea Giezl SolidumDepartment of Molecular Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Dongsu ParkDepartment of Molecular Human Genetics, Baylor College of Medicine, Houston, TX, USA. dongsu.park@bcm.edu.ORCID http://orcid.org/0000-0002-2570-3250

Funding

Hematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3M
Regulation of Skeletal progenitor cells in Osteogenesis ImperfectaR01DE031288 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI Brendan Lee, Dongsu Park · 2022 to 2026
$3.3M
WNT1 Function in Stem Cells in Osteogenesis Imperfecta and Craniofacial-Skeletal TissuesR01DE031162 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN, PARK, DONGSU · 2021 to 2025
$2.9M
Defining periosteal skeletal stem cells and novel migration mechanisms in bone regeneration and repair in vivoR01AR072018 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI PARK, DONGSU · 2018 to 2023
$2.1M
A new model for spatio-temporal coupling of bone formation and bone resorption governed by osteoclastsR61AR078073 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI, PARK, DONGSU · 2020 to 2021
$694k
NIAMS NIH HHS R01 AR072018NIAMS NIH HHS R61 AR078073NIDCR NIH HHS R01 DE031162NIDCR NIH HHS R01 DE031288NIDDK NIH HHS T32 DK060445U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR072018U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R61AR078073U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE031288
6 · The paper itself

Abstract

Regeneration of dentin and odontoblasts from dental pulp progenitor cells is essential for the maintenance of permanent tooth. However, the in vivo identity of endogenous pulp progenitor cells and how they contribute to reparative dentinogenesis remain elusive. Here we show that comparative single-cell analysis of pulp cells before and after molar eruption reveal that endogenous pulp progenitor cells are enriched in coronal papilla-like cells with Mx1-Cre and Cxcl12-GFP expression. Further, lineage tracing and fluorescence-activated cell sorting analysis indicated that Mx1-labeled (Mx1

Indexed as

Dental PulpDentinMolarMyxovirus Resistance ProteinsOdontoblastsRegenerationStem CellsAnimalsCell DifferentiationDentinogenesisMiceMice, TransgenicMyxovirus Resistance Proteins

Identifiers

PMID40804477
PMCPMC12411636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.