ArticleCancer imaging : the official publication of the International Cancer Imaging Society2025
LI-RADS: concordance between energy-integrating computed tomography, photon-counting detector computed tomography and magnetic resonance imaging.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Practical applications of photon-counting CT in oncology: an organ-based pictorial review.Insights into imaging · 2026Article
- Distinguishing enhancing from non-enhancing hyperdense adnexal lesions with spectral reconstructions at photon counting CT.Abdominal radiology (New York) · 2026Article
- Analysis of colorectal liver metastases in photon-counting detector CT - optimizing imaging through spectral reconstruction.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
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13 authors.
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Abstract
backgroundPhoton-counting detector CT (PCD-CT) offers technical advantages over energy-integrating detector CT (EID-CT) for liver imaging. However, it is unclear whether these translate into clinical improvements regarding the classification of suspicious liver lesions using the Liver Imaging Reporting and Data System (LI-RADS). This study compared the intra- and intermodal agreement of EID-CT and PCD-CT with Magnetic resonance imaging (MRI) for liver lesion classification.
methodsThis retrospective study included patients who underwent EID-CT or PCD-CT and MRI within 30 days between 02/2023 and 01/2024. Three board-certified radiologists assessed LI-RADS classification and presence of LI-RADS major features. Fleiss' Kappa and intraclass correlation coefficients (ICC) were used to evaluate rater agreement.
resultsSixty-eight lesions in 26 patients (mean age 65.0 ± 14.2 years, 19 [73.1%] male) were analyzed. Intramodal inter-rater agreement for LI-RADS classification was 0.88 (0.62-0.88) for EID-CT, 0.90 (0.83-0.94) for PCD-CT, and 0.87 (0.81-0.91) for MRI. Agreement in PCD-CT was substantial for all LI-RADS major features, whereas in EID-CT only for washout. Intermodal agreement between CT and MRI ranged from 0.67 to 0.72. Final intermodal LI-RADS classification agreement was higher for PCD-CT (0.72-0.85) than EID-CT (0.52-0.64).
conclusionsPCD-CT demonstrated higher intermodal and intramodal agreement for LI-RADS classification and major features than EID-CT. Additionally, PCD-CT shows significantly higher intramodal and inter-rater agreement for LI-RADS classification and greater concordance with MRI compared to EID-CT, reaching substantial to almost perfect agreement. These results suggest a potential benefit of PCD-CT in the management and treatment decision-making of HCC.
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