Evidence map›Paper›PMID 40804358›Full record

ArticleDrug delivery2025

Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina.

Tatyana Appelbaum, David A Smith, Kei Takahashi, Jennifer C Kwok, Hannah Sorenson, William A Beltran

Abstract read
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tatyana AppelbaumDepartment of Clinical Sciences & Advanced Medicine, Division of Experimental Retinal Therapies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-8765-4792
David A SmithDepartment of Clinical Sciences & Advanced Medicine, Division of Experimental Retinal Therapies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0009-9227-6031
Kei TakahashiDepartment of Clinical Sciences & Advanced Medicine, Division of Experimental Retinal Therapies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-7455-0465
Jennifer C KwokDepartment of Clinical Sciences & Advanced Medicine, Division of Experimental Retinal Therapies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1995-0095
Hannah SorensonDepartment of Clinical Sciences & Advanced Medicine, Division of Experimental Retinal Therapies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0004-9069-9931
William A BeltranDepartment of Clinical Sciences & Advanced Medicine, Division of Experimental Retinal Therapies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1127-4774

Funding

MODELS OF HEREDITY RETINAL DEGENERATIONR01EY006855 · NEI · UNIVERSITY OF PENNSYLVANIA · PI GUSTAVO David AGUIRRE, William A. Beltran · 1992 to 2026
$20.7M
Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Translational Research for Retinal Degeneration TherapiesR01EY017549 · NEI · UNIVERSITY OF PENNSYLVANIA · PI BELTRAN, WILLIAM A. · 2007 to 2024
$14.1M
Leica Stellaris 8 Falcon/FLIM for the PennVet Imaging CoreS10OD032305 · OD · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2023 to 2023
$842k
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY006855NEI NIH HHS R01 EY017549NIH HHS S10 OD032305
6 · The paper itself

Abstract

Efficient messenger ribonucleic acid (mRNA) delivery to the retina remains challenging. This study investigated the effects of various polyethylene glycol (PEG) derivatives on the stability and uptake of cationic lipid-based mRNA lipoplexes

Indexed as

Hyaluronic AcidPolyethylene GlycolsRetinaRNA, MessengerAnimalsCell LineDogsGene Transfer TechniquesGreen Fluorescent ProteinsLipidsLiposomesMiceRAW 264.7 CellsRetinal Pigment Epitheliumenhanced green fluorescent proteinGreen Fluorescent ProteinsHyaluronic AcidLipidsLiposomesPolyethylene GlycolsRNA, MessengermRNA lipoplexesNon-viral vectorsPEGylationretinal mRNA deliverystability

Identifiers

PMID40804358
PMCPMC12351706

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.