Evidence map›Paper›PMID 40804337›Full record

ArticleScientific reports2025

Preoperative structural networks based on DTI predicts initial subthalamic nucleus stimulation outcome in parkinson's disease.

Xiaoyue Wang, Chunyao Zhou, Fangfang Xie, Xuyang Wang, Xiaoyu Chen, Junmei Zhang, Haofei Wang, Rong Li, Xinghui He, Zhuanyi Yang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoyue WangDepartment of Neurosurgery, Xiangya Hospital, Central South University, No.87, Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, P.R. China.
Chunyao ZhouDepartment of Neurosurgery, Xiangya Hospital, Central South University, No.87, Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, P.R. China.
Fangfang XieDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Xuyang WangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China.
Xiaoyu ChenDepartment of Neurosurgery, Xiangya Hospital, Central South University, No.87, Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, P.R. China.
Junmei ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, No.87, Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, P.R. China.
Haofei WangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China.
Rong LiSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China.
Xinghui HeDepartment of Neurosurgery, Xiangya Hospital, Central South University, No.87, Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, P.R. China.
Zhuanyi YangDepartment of Neurosurgery, Xiangya Hospital, Central South University, No.87, Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, P.R. China.
Dingyang LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, No.87, Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, P.R. China.
Zhiquan YangDepartment of Neurosurgery, Xiangya Hospital, Central South University, No.87, Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, P.R. China. y66406914@163.com.

Funding

National Natural Science Foundation of China 82372085
6 · The paper itself

Abstract

Deep brain stimulation (DBS) is widely used to treat Parkinson's disease (PD), but its efficacy varies. This study aimed to investigate how preoperative structural network influences subthalamic nucleus deep brain stimulation (STN-DBS) outcome in Parkinson's disease (PD). This study retrospectively collected 93 patients, and divided them into a low improvement group (LIG) and a high improvement group (HIG). Preoperative structural networks were constructed from diffusion tensor images using probability constrained spherical deconvolution algorithm. This study compared topological characteristics between groups and explored the prognostic value of structural networks. Compared to HIG, LIG has a longer normalized characteristic path length and diminished inter-regional connections within left frontal lobe. Normalized characteristic path length is negatively correlated with DBS outcome, while connection strength is positively correlated with DBS outcome. Notably, the fusion method of clinical phenotype and network characteristics has better predictive power for postoperative DBS outcome than either the clinical method or the network method. This study reveals that both normalized characteristic path length and connectivity between the left superior frontal gyrus (central region) and the left medial frontal gyrus (ventral lateral region) are associated with initial DBS efficacy, which could be preoperative biomarkers of DBS outcome.

Indexed as

Deep Brain StimulationDiffusion Tensor ImagingNerve NetParkinson DiseaseSubthalamic NucleusAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesTreatment OutcomeBrain networkDeep brain stimulationDTIParkinson’s disease

Identifiers

PMID40804337
PMCPMC12350905

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.