Evidence map›Paper›PMID 40804318›Full record

ArticleScientific reports2025

Prevalence, safety, and role of nicotine pouches in smoking cessation among smokers and the public in Saudi Arabia.

Hassan Alwafi, Abdallah Y Naser, Ranad Alharbi, Sara Tawakkul, Aseel Albayhie, Wed Alsaiari, Joud Aloqilyi, Layan Althagafi, Abdulelah M Aldhahir, Abdullah A Alqarni and 6 more

Erratum issuedAbstract read
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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Hassan AlwafiDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia. hhwafi@uqu.edu.sa.
Abdallah Y NaserDepartment of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan.
Ranad AlharbiDepartment of Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Sara TawakkulDepartment of Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Aseel AlbayhieDepartment of Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Wed AlsaiariDepartment of Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Joud AloqilyiDepartment of Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Layan AlthagafiDepartment of Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Abdulelah M AldhahirRespiratory Therapy Program, Department of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Abdullah A AlqarniDepartment of Respiratory Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Jaber S AlqahtaniDepartment of Respiratory Care, Prince Sultan Military College of Health Sciences, 34313, Dammam, Saudi Arabia.
Saeed M AlghamdiClinical Technology Department, Respiratory Care Program, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Saleha KhanCollege of Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia.
Hamza AlsaggafDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Mohammad Saleh DairiDepartment of Medicine, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Alaa A AlsharifDepartment of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotine pouches are becoming increasingly popular. However, there's still a lack of comprehensive data on how widespread nicotine pouch use and its side effects in Saudi Arabia. This study aims to investigate the prevalence and associated side effects of the use of nicotine pouches among smokers and the public in Saudi Arabia. This study also investigated their utilization in smoking cessation. This study used an online cross-sectional questionnaire-based design. The study population included individuals over the age of 18 living in Saudi Arabia. The questionnaire was distributed through social media platforms. Statistical analysis was conducted using SPSS software. Descriptive statistics were used to generate means and percentages. Regression analysis was performed to predict factors associated with the use of nicotine pouches for the purpose of smoking cessation. A total of 657 participants were included in the analysis. Regarding age distribution, the majority were aged between 18 and 30 years. Most participants were male (422; 64.2%). Regarding the prevalence of nicotine pouches use, (21.2%) had tried the pouches before. Among those who had used nicotine pouches, 57 participants (41.0%) reported success in quitting smoking, while 53 participants (38.1%) experienced only a little success, and 29 participants (20.9%) were unsuccessful. The most common adverse effect was nausea (88, 13.4%), followed by fatigue (44, 6.7%) and headache (43, 6.5%). Participants who smoked 4-6 cigarettes per day, 7-9 cigarettes per day, or more than 10 cigarettes per day had higher odds of nicotine pouch use (OR = 3.70,95% CI = 1.14-11.96, p = 0.02), (OR = 6.74,95% CI = 1.71-26.5, p = 0.006) and (OR = 2.59,95% CI = 1.07-6.26, p = 0.03). This study showed a promising result of the use of nicotine pouches and success in quitting smoking in Saudi Arabia population. Most of the side effects reported in the study were mild. However, future studies with larger sample size and analytical design are needed.

Indexed as

NicotineSmokersSmokingSmoking CessationAdolescentAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceSaudi ArabiaSurveys and QuestionnairesYoung AdultNicotineDescriptive studyNicotineNicotine pouchesPrevalenceSaudi ArabiaSmokersSmoking

Identifiers

PMID40804318
PMCPMC12350803

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.