ArticleNPJ microgravity2025
Increasing seated reaction forces with lower body negative pressure.
Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
This study evaluates ground reaction forces and cardiovascular responses during seated lower body negative pressure (LBNP). Ten healthy subjects were exposed to randomized LBNP levels (-10 to -40 mmHg) while seated in a sealed chamber. Gluteal, foot, and total reaction forces, along with heart rate and blood pressure, were measured at each level. Reaction forces increased significantly with rising LBNP (P < 0.05), exceeding baseline at 10 mmHg and doubling by 30 mmHg. Cardiovascular parameters remained stable, indicating no acute hemodynamic risk. Force generation was dependent on LBNP amplitude and waist cross-sectional area. These findings suggest that seated LBNP is a safe and effective method to simulate Earth-like seated posture in microgravity, offering a promising countermeasure to mitigate musculoskeletal deconditioning and support gravitational adaptation during long-duration spaceflight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.