Evidence map›Paper›PMID 40804305›Full record

ArticleNature communications2025

An organometallic approach to the synthesis of heteropolycyclic compounds from benzenes.

Paolo Siano, Louis A Diment, Daniel J Siela, Megan N Ericson, Matt McGraw, Benjamin F Livaudais, Diane A Dickie, W Dean Harman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paolo SianoDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Louis A DimentDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0009-0003-9817-1931
Daniel J SielaDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Megan N EricsonDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Matt McGrawDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0009-0002-5870-5049
Benjamin F LivaudaisDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Diane A DickieDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-0939-3309
W Dean HarmanDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA. wdh5z@virginia.edu.ORCID http://orcid.org/0000-0003-0939-6980

Funding

Rapid Synthesis of Topologically Complex Molecules with Tungsten Dearomatization AgentsR35GM152065 · NIGMS · UNIVERSITY OF VIRGINIA · PI Walter Dean Harman · 2024 to 2026
$1.4M
Rapid Synthesis of Topologically Complex Molecules with Tungsten Dearomatization AgentsR01GM132205 · NIGMS · UNIVERSITY OF VIRGINIA · PI HARMAN, WALTER DEAN · 2019 to 2022
$1.3M
National Science Foundation (NSF) CHE-2018870NIGMS NIH HHS R01 GM132205NIGMS NIH HHS R35 GM152065U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM132205U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM152065
6 · The paper itself

Abstract

The emerging field of dearomatization capitalizes on the synthetic potential of aromatic molecules. By using a transition metal to bind to two carbons of a benzene ring, the remaining four carbons are left available for the attachment of various chemical fragments. If these fragments are connected, this process could be a blueprint for synthesizing polycyclic architectures. The objective of this study is to develop a modular approach for creating classes of saturated polycyclic compounds that are currently underrepresented in the landscape of druggable chemical space. Herein, the phenyl group of methylphenylsulfone is coordinated to the tungsten complex {WTp(NO)(PMe

Identifiers

PMID40804305
PMCPMC12350676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.