Evidence map›Paper›PMID 40804135›Full record

ArticleScientific reports2025

The impact of different types of brain injuries on cerebral perfusion in preterm infants: an arterial spin labeling : MRI study.

Chen Zhang, Wenli Li, Huiying Fan, Ming Niu, Hao Song, Huifang Dong, Qing Yan, Falin Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chen ZhangDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wenli LiDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huiying FanDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ming NiuDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hao SongDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huifang DongDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Qing YanDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Falin XuDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. xufalin72@126.com.

Funding

the Henan Medical Science and Technique Foundation LHGJ20190350the Open project of the Clinical Medical Research Center of Pediatric Disease in Henan Province KFKT2021103
6 · The paper itself

Abstract

Cerebral blood flow (CBF) is crucial for supplying the brain with the oxygen and nutrients necessary for its proper development and metabolism. The poor autoregulation of CBF is believed to play a role in the development of brain injury in preterm infants. This study aimed to investigate the characteristics of CBF in perinatal brain injury. In this retrospective study, 108 healthy preterm infants (HP), 26 infants with intracranial hemorrhage (IVH), and 16 infants with periventricular leukomalacia (PVL) were included. CBF was assessed using arterial spin labeling imaging in the frontal, temporal, parietal, and occipital cortex, as well as the basal ganglia and thalamus. After adjusting for gestational age, postmenstrual age (PMA) at MRI scan, and birth weight, the PVL hemispheres exhibited consistently reduced CBF in various gray matter regions compared to the HP and IVH hemispheres, including the frontal, temporal, parietal, and occipital cortex, as well as the basal ganglia and thalamus. The comparison of HP and IVH hemispheres revealed decreased CBF in IVH hemispheres in the frontal, parietal, occipital cortex, as well as in the basal ganglia and thalamus. In multifactor linear regression models, the PMA at MRI scan, 5 min Apgar score, brain injury, and neonatal necrotizing stage ≥ 2 are independent factors affecting cerebral perfusion.

Indexed as

Brain InjuriesCerebrovascular CirculationIntracranial HemorrhagesLeukomalacia, PeriventricularMagnetic Resonance ImagingBrainFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleRetrospective StudiesSpin LabelsSpin LabelsArterial spin labeling imagingBrain injuryCerebral blood flowCerebral cortexPreterm infant

Identifiers

PMID40804135
PMCPMC12350612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.