Evidence map›Paper›PMID 40804081›Full record

ArticleScientific reports2025

Nationwide study of spondyloarthritis spectrum and disease characteristics in Egypt.

Yasser Emad, Ahmed Elsaman, Hanan El-Saadany, Rawhya R ElShereef, Yousra Hisham, AlShaymaa Farouk, Gehad G Elsehrawy, Samar Tharwat, Marwa A Amer, Osman Hammam and 11 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yasser EmadRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed ElsamanRheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Hanan El-SaadanyRheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt.
Rawhya R ElShereefRheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Yousra HishamRheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
AlShaymaa FaroukInternal Medicine Department, Rheumatology unit, Faculty of Medicine, Ain Shams university, Cairo, Egypt.
Gehad G ElsehrawyRheumatology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Samar TharwatInternal Medicine Department, Rheumatology unit, Faculty of Medicine, Mansoura university, El Gomhouria St, Mansoura, Dakahlia, Egypt. samartharwat2000@mans.edu.eg.
Marwa A AmerRheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Osman HammamRheumatology Department, Faculty of Medicine, New Vally University, New Valley, Egypt.
Nevin HammamRheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt.
Amany S ElBahnasawyRheumatology Department, Faculty of Medicine, Mansoura university, Dakahlia, Egypt.
Rasha FawzyRheumatology Department, Faculty of Medicine, Benha University, Benha, Kalyoubia, Egypt.
Fatemah ElshabacyRheumatology Department, Benha Teaching Hospital, Benha, Kalyoubia, Egypt.
Asmaa KhalifaRheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Abdelhfeez MoshrifRheumatology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
Faten IsmailRheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Shereen ElwanRheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt.
Mahmoud A AbdelsalamRheumatology Department, Faculty of Medicine, Kafr ElSheikh University, Kafr ElSheikh, Egypt.
Amira M IbrahimRheumatology Department, Faculty of Medicine, Kafr ElSheikh University, Kafr ElSheikh, Egypt.
Tamer A GheitaRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to describe the array and disease characteristics of spondyloarthritis (SpA) across Egypt. This work included 1401 SpA patients recruited from 15 specialized Egyptian rheumatology centers representing 20 major cities. The demographic and clinical features, as well as the therapeutic data, were recorded. The mean age of the patients was 37.6 ± 11.4 years, disease duration 8.01 ± 6.7 years, and age at onset 29.9 ± 11 years; 148 (10.6%) were juvenile-onset. There were 813 males and 588 females (M: F 1.4:1). 5.7% were diabetic, 6.1% hypertensive, and 19.3% were smokers. The mean BASDAI was 3.98 ± 1.78, and the BASFI was 4.02 ± 1.77. The human leukocytic antigen (HLA-B27) was positive in 19.8%. Biologic therapy was received by 55.5%, followed by methotrexate (36%) ,steroids (10.8%), and sulfasalazine in 10.7%. In males, the age at onset was significantly lower (p = 0.02), while radiographic axSpA, neuropsychiatric and pulmonary manifestations, HLA-B27 positivity, and receiving biologic therapy were significantly higher (p = 0.02, p < 0.0001, p = 0.03, p < 0.0001, and p < 0.0001). In females, cutaneous manifestations and arthritis were significantly more frequent (p < 0.0001 and p < 0.0001). Those with positive HLA-B27 had a significantly higher frequency of AS (73%) (p = 0.003), male gender (66.2%) (p < 0.0001), longer disease duration (p = 0.001), and were receiving a higher frequency of biologic therapy (89%, p < 0.0001). Radiographic axial SpA was most reported from Assuit (15.9%), nr-axSpA from Cairo (24.5%), peripheral arthritis only from Giza (30.7%), and unclassified from Kafr ElSheikh (33.9%) (p = 0.002). The spectrum of SpA in Egypt is inconsistent across the country. Gender, disease subtype, and HLA-B27 seem to play a key role in the phenotypic presentation.

Indexed as

SpondylarthritisAdolescentAdultAge of OnsetEgyptFemaleHLA-B27 AntigenHumansMaleMiddle AgedYoung AdultHLA-B27 AntigenAge at onsetBiologicsEgyptGenderMulticenterSpondyloarthritis

Identifiers

PMID40804081
PMCPMC12350779

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