Evidence map›Paper›PMID 40803859›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Detection of Irpex lacteus in the Lung in a Case with Microscopic Polyangiitis-mimicking Manifestations Positive for Myeloperoxidase-antineutrophil Cytoplasmic Antibody.

Eiko Kawakami, Yukari Kamada, Shoichi Fukui, Takashi Jubashi, Kanako Kojima, Toshimasa Shimizu, Kazuaki Takeda, Katsunori Yanagihara, Atsushi Kawakami

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eiko KawakamiDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yukari KamadaDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Shoichi FukuiDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Takashi JubashiDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Kanako KojimaDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Toshimasa ShimizuDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Kazuaki TakedaDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Katsunori YanagiharaDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Atsushi KawakamiDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antineutrophil cytoplasmic antibody (ANCA) testing is valuable for the diagnosis of ANCA-associated vasculitis; however, ANCA can be positive in infectious diseases. We herein report a case of myeloperoxidase (MPO)-ANCA-positive microscopic polyangiitis-mimicking manifestations in which the bronchoalveolar lavage was positive for Irpex lacteus. After initiating treatment for I. lacteus with isavuconazole, the patient's symptoms of pain in the lower legs improved, and MPO-ANCA became negative. This case provides speculation on the relationship between fungus and ANCA production and highlights the importance of an exhaustive search for infectious agents when administering immunosuppressive therapies.

Indexed as

Antibodies, Antineutrophil CytoplasmicLungMicroscopic PolyangiitisPeroxidaseAgedDiagnosis, DifferentialHumansMaleMiddle AgedAntibodies, Antineutrophil CytoplasmicPeroxidaseIrpex lacteusisavuconazolemicroscopic polyangiitismyeloperoxidase-antineutrophil cytoplasmic antibody

Identifiers

PMID40803859
PMCPMC13070592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.