Evidence map›Paper›PMID 40803853›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Diffusion-weighted Whole-body Imaging with Background Body Signal Suppression Enables Simultaneous Whole-body Assessments of IgG4-related Diseases.

Wataru Ujita, Terumi Kamisawa, Kazuro Chiba, Hiroki Tabata, Jun Nakahodo, Mizuka Suzuki, Keigo Setoguchi, Yoshinori Igarashi, Takahisa Matsuda

Abstract read
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Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wataru UjitaDepartment of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
Terumi KamisawaDepartment of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
Kazuro ChibaDepartment of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
Hiroki TabataDepartment of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
Jun NakahodoDepartment of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
Mizuka SuzukiCenter of IgG4-related Disease, Tokyo Metropolitan Komagome Hospital, Japan.
Keigo SetoguchiDepartment of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
Yoshinori IgarashiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, Japan.
Takahisa MatsudaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective IgG4-related disease (IgG4-RD) is a systemic condition that frequently involves multiple organs. This study examined the utility of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) for the diagnosis and monitoring of IgG4-RD. Methods Twenty patients underwent DWIBS for the diagnosis of IgG4-RD. Of these, six did so after steroid therapy. The extent of high-intensity areas visible on DWIBS was compared to that on computed tomography (CT). Changes in signal enhancement and apparent diffusion coefficient (ADC) values on DWIBS were analyzed following steroid therapy. Results In addition to 20 main IgG4-RD lesions, areas of high intensity were detected on DWIBS in 28 lesions in 8 organs and the retroperitoneum. The high-intensity areas on DWIBS also appeared as a mass or thickness on CT, except in three areas in the kidneys and retroperitoneum, but segmental wall thickness of the bile duct in two patients was undetectable on DWIBS. On the second DWIBS procedure following steroid therapy, all 16 high-intensity areas displayed some degree of improvement, including complete resolution (n=3), disappearance of high signal intensity and a decrease in the size of the lesion (n=6), and a decrease in both signal intensity and lesion size (n=7). Furthermore, the ADC value of 13 areas significantly increased after steroid therapy (1.32±0.24×10

Indexed as

Diffusion Magnetic Resonance ImagingImmunoglobulin GImmunoglobulin G4-Related DiseaseWhole Body ImagingAdultAgedFemaleHumansMaleMiddle AgedTomography, X-Ray ComputedImmunoglobulin Gautoimmune pancreatitisdiffusion-weighted whole body imaging with background body signal suppression (DWIBS)IgG4IgG4-related diseasesteroid

Identifiers

PMID40803853
PMCPMC13019011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.