Evidence map›Paper›PMID 40803819›Full record

SynthesisRMD open2025

Assessing the

Carlos Rosa-Baez, Carlos Rangel-Pelaez, Inmaculada Rodriguez-Martin, Martin Kerick, Alfredo Guillen-Del-Castillo, Carmen P Simeon-Aznar, José Luis Callejas, Alexandre E Voskuyl, Alexander Kreuter, Oliver Distler and 14 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in RMD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Carlos Rosa-BaezDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.ORCID 0000-0002-1257-3338
Carlos Rangel-PelaezDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.ORCID 0000-0001-7697-1696
Inmaculada Rodriguez-MartinDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.ORCID 0000-0001-5413-1581
Martin KerickDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.ORCID 0000-0002-6298-4514
Alfredo Guillen-Del-CastilloUnit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain.ORCID 0000-0003-0626-507X
Carmen P Simeon-AznarUnit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
José Luis CallejasDepartment of Internal Medicine, Hospital San Cecilio, Granada, Spain.
Alexandre E VoskuylDepartment of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and immunology Center, Amsterdam UMC, Amsterdam, Netherlands.
Alexander KreuterDepartment of Dermatology, Venereology, and Allergology, Helios St. Elisabeth Klinik Oberhausen, University Witten-Herdecke, Oberhausen, Germany.
Oliver DistlerDepartment of Rheumatology, University Hospital Zürich Center of Experimental Rheumatology, Zürich, Switzerland.ORCID 0000-0002-0546-8310
Susanna M ProudmanRheumatology Unit, Royal Adelaide Hospital and University of Adelaide, Adelaide, Victoria, Australia.
Mandana NikpourUniversity of Sydney School of Public Health, Royal Prince Alfred Hospital Sydney, and Sydney MSK Research Flagship Centre, University of Sydney, Sydney, New South Wales, Australia.
Nicolas HunzelmannDepartment of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
Jeska K De Vries-BouwstraDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-5624-1415
Ariane L HerrickCentre for Musculoskeletal Research, The University of Manchester, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.ORCID 0000-0003-4941-7926
Yannick AllanoreDepartment of Rheumatology, Université Paris Cité UFR de Médecine, Paris, France.
Lorenzo BerettaReferral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.ORCID 0000-0002-6529-6258
Maureen D MayesDivision of Rheumatology, Department of internal medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Christopher P DentonDivision of Medicine, University College London, London, UK.
Shervin AssassiDivision of Rheumatology, Department of internal medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Javier MartinDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.
Marialbert Acosta-HerreraDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain m.acostaherrera@ipb.csic.es.ORCID 0000-0002-9868-6535
International SSc Group
Australian Scleroderma Interest Group (ASIG)

Funding

Interferon Regulatory Factor 7 Links Interferon Pathway Activation to the Exaggerates Fibrotic Response in Systemic SclerosisR01AR081280 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Shervin Assassi, Minghua Wu · 2023 to 2026
$1.1M
Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic SclerosisR61AR078078 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ASSASSI, SHERVIN, LARIN, KIRILL V · 2020 to 2022
$780k
Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic SclerosisR33AR078078 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ASSASSI, SHERVIN, LARIN, KIRILL V · 2023 to 2023
$389k
NIAMS NIH HHS R01 AR081280NIAMS NIH HHS R33 AR078078NIAMS NIH HHS R61 AR078078
6 · The paper itself

Abstract

objectiveThe common gain-of-function variant rs35705950, located in the promoter of

methodsSamples were collected from blood/saliva, followed by DNA extraction and genotyping using SNP arrays. Data for rs35705950 and additional 903 variants within 100 Kb were obtained using genomic imputation. Subsequently, we tested their association in a meta-analysis to increase the consistency of the results, including 10 European ancestry cohorts comprising 2363 patients with SSc-ILD, 3526 SSc patients without ILD and 15 076 controls.

resultsMeta-analysis showed no significant association between rs35705950 and SSc-ILD, either comparing patients with SSc with and without ILD (p value: 0.588, OR: 1.05, 95% CI: 0.87 to 1.27) nor patients with SSc-ILD with controls (p value: 0.061, OR: 1.16, 95% CI: 0.99 to 1.36). Moreover, none of the additional 903 variants tested in the genomic region reached statistical significance.

conclusionDespite analysing the largest and most statistically powered SSc-ILD cohort to date, we found no evidence of association between the

Indexed as

Genetic Predisposition to DiseaseLung Diseases, InterstitialMucin-5BPolymorphism, Single NucleotidePromoter Regions, GeneticScleroderma, SystemicAdultAgedAllelesFemaleGenetic Association StudiesGenotypeHumansMaleMiddle AgedMUC5B protein, humanMucin-5BLung Diseases, InterstitialPolymorphism, GeneticScleroderma, Systemic

Identifiers

PMID40803819
PMCPMC12352244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.