ArticleGut2025
Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes.
Article in Gut, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The gut microbiota-bile acid axis in liver transplantation: implications for postoperative complications and therapeutic strategies.Frontiers in microbiology · 2026Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver transplantation (LT) remains hampered by post-transplant complications. While gut microbiota dysbiosis has been linked to transplant outcomes, the role of the intrahepatic graft's native microbiota remains unexplored.
objectiveTo characterise the microbial profile detected in organ preservation solution (OPS) and determine whether specific microbial taxa are associated with short-term clinical outcomes, and to develop predictive models for risk stratification.
designWe analysed the OPS microbiota-based metataxonomic signature from 110 LT donors (discovery cohort) and an independent validation cohort (n=29) using 16S rRNA sequencing. Microbial DNA signatures associated with clinical outcomes were identified through MaAsLin2-adjusted models, and relevant gene pathways were uncovered via data mining and enrichment analysis. Machine learning (ML) models were developed to predict outcomes based on microbial features, and host-microbiome interactions were validated through RNA sequencing (RNA-seq of matched liver biopsies).
resultsOPS-derived microbial DNA signature closely resembled liver/bile microbiomes (Proteobacteria-dominated). Specific genera (eg,
conclusionDonor intrahepatic microbial DNA signature predicts LT outcomes via immune-metabolic modulation. While causality requires further study, these findings position the graft microbiome as a novel biomarker and potential therapeutic target, paving the way for microbiome-informed precision care in transplantation.
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