Evidence map›Paper›PMID 40803735›Full record

Observational studyBMJ open2025

The INfectious DIsease REgistry BIObank (INDI-REBIO): protocol for the design and implementation of a single-centre, prospective registry and biobank in a tertiary care centre in Italy for advancing infectious disease research.

Marco Ripa, Laura Galli, Paola Cinque, Silvia Nozza, Vincenzo Spagnuolo, Chiara Tassan Din, Monica Guffanti, Riccardo Lolatto, Girolamo Piromalli, Silvia Carletti and 7 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06418048 (Prospective Registry and Biobank of Patients With Infectious Diseases), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06418048 recruitingnot on this map

Prospective Registry and Biobank of Patients With Infectious Diseases

Typeobservational_patient_registrySponsorIRCCS San RaffaeleRan2024 to 2044Enrolled10,000ConditionsBloodstream Infections, Central Nervous System Infections, Bone and Joint Infections, Endovascular Infections
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marco RipaUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy ripa.marco@hsr.it.ORCID http://orcid.org/0000-0002-6380-0377
Laura GalliUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Paola CinqueUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Silvia NozzaUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-2673-2731
Vincenzo SpagnuoloUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Chiara Tassan DinUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Monica GuffantiUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Riccardo LolattoUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Girolamo PiromalliUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Silvia CarlettiLaboratory of Microbiology and Virology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Massimo LocatelliLaboratory of Microbiology and Virology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesca SanvitoPathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Maurilio PonzoniVita-Salute San Raffaele University, Milan, Italy.
Elisa CantarelliBiological Resource Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cristina TresoldiBiological Resource Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Antonella CastagnaUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
INDI-REBIO Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInfectious diseases are a major global health concern, responsible for significant morbidity and mortality. To advance the understanding and treatment of these diseases, biobanks and biorepositories play a crucial role in guaranteeing sample traceability through their entire life cycle (collection, acquisition and registration, processing, storage, distribution) and future analysis of clinical and biological data. METHODS AND ANALYSIS: The INfectious DIsease REgistry BIObank (INDI-REBIO) is an observational, prospective, monocentric, open-ended registry with ad hoc procedures and a systematic collection of uniform clinical, laboratory, imaging and therapeutic data of patients with suspected or microbiologically documented bacterial, viral, fungal and parasitic infectious diseases from the IRCCS San Raffaele Hospital (Milan, Italy). The study aims to collect both uniform data and biological samples such as blood and other relevant specimens. The registry aims to include significant patient numbers across various conditions (among others: bloodstream infections, endovascular infections as infective endocarditis, central nervous system infections, bone and joint infections, multidrug-resistant organisms (MDROs) colonisation, sexually transmitted infections, HIV infection, emerging and re-emerging infectious diseases), enabling comprehensive research on disease evolution, treatment outcomes and the identification of biomarkers. ETHICS AND DISSEMINATION: The study adheres to ethical principles outlined by the Helsinki Declaration and Good Clinical Practice guidelines. It has received ethical approval (Comitato Etico CET Lombardia 1, CET 138-2023) and is registered on clinicaltrials.gov (NCT06418048). Participants will provide informed consent and can withdraw at any time. The study results will be disseminated through major international conferences and submitted to peer-reviewed research journals. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov, NCT06418048.

Indexed as

Biological Specimen BanksBiomedical ResearchCommunicable DiseasesRegistriesHumansItalyProspective StudiesResearch DesignTertiary Care CentersINFECTIOUS DISEASESMICROBIOLOGYREGISTRIES

Identifiers

PMID40803735
PMCPMC12352187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.