ArticleJournal of biophotonics2025
Curcumin Internalization in Streptococcus mutans Biofilms: A Confocal Microscopy Analysis.
Article in Journal of biophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Curcumin-Based Nanoformulations for Oral Health: Mechanistic Insights, Antimicrobial Efficacy, and Future Clinical Perspectives.Biomedicines · 2026Review
- Targeting the Dynamic Susceptibility Window: Time-Sensitive Photodynamic Synergy With Antibiotics Against Streptococcus spp.Lasers in surgery and medicine · 2026Article
- Curcumin Internalization in Streptococcus mutans Biofilms: A Confocal Microscopy Analysis.Journal of biophotonics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Streptococcus mutans is one of the main harmful agents to oral health, exhibiting high resistance in its biofilm form. This study evaluated curcumin as a photosensitizer in photodynamic inactivation (PDI), monitoring its internalization time and activity. The biofilm was cultured for 24 h and treated with curcumin activated by two-photon excitation (800 nm). After photodegradation, curcumin continued to penetrate effectively into the biofilms, replacing previously degraded molecules with new ones and constantly generating reactive species (ROS and singlet oxygen) capable of damaging the bacteria. This contrasts with previous studies that reported limitations of natural photosensitizers in this context. Therefore, the principal contribution of this study is the in vitro demonstration of the dynamic efficacy of curcumin in the complex biofilm environment. The use of confocal microscopy was essential to visualize and quantify the effects of curcumin, highlighting its value as an analytical tool in the evaluation of biofilm treatments.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.