Evidence map›Paper›PMID 40803711›Full record

SynthesisTropical medicine & international health : TM & IH2025

Effects of Communication Strategies on Treatment Adherence and Success in Tuberculosis: A Systematic Review and Meta-Analysis.

Omar Oliveira Meira, Luiz Gustavo Ribeiro Silva, Raquel Fonseca Sales, Renata Maria Colodette, Lucas Borges Gomes Ferreira Pinto, Emily de Souza Ferreira, Rosângela Minardi Mitre Cotta, Tiago Ricardo Moreira

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Tropical medicine & international health : TM & IH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Omar Oliveira MeiraGraduate Program in Health Sciences, Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0009-0009-7743-6148
Luiz Gustavo Ribeiro SilvaDepartment of Medicine and Nursing, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0009-0005-4713-6671
Raquel Fonseca SalesDepartment of Medicine and Nursing, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0009-0008-4894-1367
Renata Maria ColodetteDentistry Course, Health Sciences Center, Viçosa University Center (UNIVIÇOSA), Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-2976-881X
Lucas Borges Gomes Ferreira PintoDepartment of Medicine and Nursing, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-7936-3343
Emily de Souza FerreiraGraduate Program in Nutrition Science, Department of Health Nutrition, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-4451-0611
Rosângela Minardi Mitre CottaGraduate Program in Nutrition Science, Department of Health Nutrition, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-5331-9734
Tiago Ricardo MoreiraGraduate Program in Health Sciences, Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-6606-4942

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02901-24
6 · The paper itself

Abstract

introductionTuberculosis, although curable, presents challenges related to treatment adherence, which compromises treatment effectiveness. Individual, social and structural barriers interfere with patients' ability to properly follow the therapeutic regimen, thereby impacting treatment outcomes. Given the limitations of the conventional healthcare model, which relies primarily on in-person consultations and standard treatment protocols without additional adherence support technologies, new approaches have been explored to improve patient outcomes. This study seeks to identify effective communication approaches in this context.

objectiveTo identify the most effective communication strategies to optimise treatment adherence and improve therapeutic success in patients diagnosed with tuberculosis.

methodsA systematic review with meta-analysis was conducted. We included studies available in the MEDLINE (via PubMed), EMBASE and SCOPUS databases, with publication dates between January 2005 and December 2024. The primary outcomes were adherence to and success in tuberculosis treatment.

resultsThis systematic review included 17 studies on tuberculosis treatment adherence. Of these, 12 were included in the meta-analysis for adherence and 8 for treatment success. The most effective strategies for adherence were community education (2 studies; RR: 0.25, 95% CI: 0.11-0.56) and video observed therapy (VDOT) (2 studies; RR: 0.29, 95% CI: 0.21-0.40). The combination of electronic devices with SMS also showed positive results (3 studies; RR: 0.53, 95% CI: 0.37-0.77). SMS alone (5 studies) and electronic devices alone (3 studies) were not effective. For treatment success, only the combination of electronic devices with SMS (RR: 0.31, 95% CI: 0.17-0.55) and community education (RR: 0.51, 95% CI: 0.40-0.64) were effective.

conclusionThe combination of electronic devices with SMS and community education is an effective strategy for improving adherence and therapeutic success in tuberculosis treatment. Isolated interventions with SMS or electronic technologies did not show significant results. Adapting approaches to local realities is crucial for optimising outcomes.

Indexed as

Antitubercular AgentsCommunicationMedication AdherenceTreatment Adherence and ComplianceTuberculosisHumansAntitubercular Agentscommunicationmeta‐analysistreatment adherence and compliancetuberculosis

Identifiers

PMID40803711
PMCPMC12501552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.