Evidence map›Paper›PMID 40803683›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2026

Maternal expressions of warmth and negativity and adolescent mental health: using longitudinal monozygotic twin-difference analyses to approach causal inference.

Alice Wickersham, Avshalom Caspi, Louise Arseneault, Terrie E Moffitt, Johnny Downs, Antony Ambler, Rachel M Latham, Nicholas Cummins, Zoë Firth, Jasmin Wertz and 1 more

Abstract readTwin Study
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Alice WickershamCAMHS Digital Lab, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-7402-7690
Avshalom CaspiSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Louise ArseneaultSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-2938-2191
Terrie E MoffittSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Johnny DownsCAMHS Digital Lab, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-8061-295X
Antony AmblerSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Rachel M LathamSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Nicholas CumminsCAMHS Digital Lab, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Zoë FirthCAMHS Digital Lab, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Jasmin WertzDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Helen L FisherSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0003-4174-2126

Funding

Science CoreP2CHD065563 · NICHD · DUKE UNIVERSITY · PI Giovanna M Merli · 2015 to 2026
$5.7M
Neuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8M
Economic and Social Research Council ES/S012567/1Economic and Social Research Council ES/W002531/1Medical Research Council G1002190Medical Research Council MR/L017105/1Medical Research Council MR/X002721/1Medical Research Council MR/X010791/1National Institute for Health and Care Research CS-2018-18-ST2-014National Institute of Child Health and Human Development HD077482NICHD NIH HHS P2C HD065563NICHD NIH HHS R01 HD077482
6 · The paper itself

Abstract

backgroundEmotions that mothers express about their offspring are associated with offspring mental health during childhood, but little research has explored whether this extends into adolescence. We investigated associations between maternal warmth and negativity towards twin offspring at age 10, and subsequent mental health outcomes in early and late adolescence.

methodsThe Environmental Risk (E-Risk) Longitudinal Twin Study is a population-based cohort of 2,232 same-sex twins born in 1994-1995 across England and Wales. Maternal warmth and negativity were assessed from Five-Minute Speech Samples obtained when twins were aged 10. Continuous mental health outcomes were assessed in interviews with twins at ages 12 (depression, anxiety, attention-deficit hyperactivity disorder and conduct disorder) and 18 (general psychopathology, internalising, externalising and thought disorder). Linear regressions were conducted on 1906 participants with available data and adjusted for sex, family socioeconomic status, and age-5 emotional and behavioural problems. We then conducted a monozygotic twin-difference analysis to control for unmeasured shared environmental and genetic factors.

resultsLower maternal warmth and higher maternal negativity were associated with worse mental health outcomes at ages 12 and 18. For example, when comparing differences in mothers' expressed emotions and mental health outcomes within monozygotic twin pairs, higher negativity remained associated with externalising symptoms (b = 1.77, 95% CI = 0.68 to 2.86, β = .14) and poorer general psychopathology (b = 1.82, 95% CI = 0.63 to 3.01, β = .13), and lower warmth with externalising symptoms (b = -1.96, 95% CI = -3.54 to -0.37, β = -.11). These associations remained after adjusting for twin-differences in age-5 emotional and behavioural problems and birth weight. Null findings were more frequently observed for maternal warmth and internalising outcomes.

conclusionsUsing a genetically sensitive design to approach causal inference, we found evidence for associations between maternal warmth/negativity and adolescent mental health outcomes. Maternal expressed emotion ratings might provide an early opportunity to identify families who would benefit from interventions and mental health disorder prevention programmes.

Indexed as

Maternal BehaviorMental DisordersMother-Child RelationsAdolescentChildEnglandFemaleHumansLongitudinal StudiesMaleTwins, MonozygoticWalesadolescencecohort studyExpressed emotionmental healthparentingtwins

Identifiers

PMID40803683
PMCPMC12699114

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.