Evidence map›Paper›PMID 40803676›Full record

Trial reportJournal of adolescent and young adult oncology2026

Effect of Acupuncture and Massage on Pain in Adolescent and Young Adult Patients with Advanced Cancer: Subgroup Analysis of a Randomized Clinical Trial.

Han-Wei V Wu, Xiaotong Li, Qing S Li, Raymond E Baser, Katherine S Panageas, Susan Chimonas, William D Tap, Julia Glade Bender, Chaya S Moskowitz, Jun J Mao

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of adolescent and young adult oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Han-Wei V WuDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0009-0002-2834-8407
Xiaotong LiIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Qing S LiIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Raymond E BaserDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Katherine S PanageasDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Susan ChimonasDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
William D TapDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Julia Glade BenderDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Chaya S MoskowitzDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jun J MaoIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Oncology-focused Postdoctoral Training in Care Delivery and Symptom Science (OPTICS)T32CA275764 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JONINE L. BERNSTEIN, JUN J MAO · 2023 to 2026
$1.8M
NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA275764
6 · The paper itself

Abstract

purposePain management remains challenging for adolescent and young adult (AYA) cancer patients. Acupuncture and massage have been recommended for cancer-related pain management, but no prospective trials have been conducted in AYA patients. We explored the effects of acupuncture and massage on pain in AYAs.

methodsThis subgroup analysis focused on AYA patients (aged 18-39 years) enrolled in a randomized controlled trial comparing acupuncture and massage for pain management in advanced cancer. Interventions were delivered weekly for 10 weeks, followed by monthly booster treatments through week 26. The primary outcome was the worst pain score from the Brief Pain Inventory, analyzed using a linear mixed-effects model.

resultsThirty participants met eligibility criteria (13 acupuncture; 17 massage), with a mean age of 31.1 years (standard deviation, 5.8); 57% were female; 67% were White; and 53% had solid tumors. Both groups experienced reduced pain over time. Relative to baseline, patients receiving acupuncture had a mean change of -1.26 points (95% confidence interval [CI], -2.54 to 0.01) at 10 weeks and a mean change of -1.46 points (95% CI, -2.78 to -0.14) at 26 weeks. Patients receiving massage experienced a mean change of -2.81 points (95% CI, -3.92 to -1.70) at week 10 and a mean change of -3.79 points (95% CI, -4.85 to -2.73) at week 26.

conclusionAYA patients with advanced cancer who received either acupuncture or massage experienced clinically meaningful and sustained reductions in pain. These findings provide a promising foundation for future trials aimed at evaluating integrative pain management strategies in AYAs.

Indexed as

Acupuncture TherapyCancer PainMassageNeoplasmsPain ManagementAdolescentAdultFemaleHumansMaleYoung Adulthealth-related quality of lifepain managementquality of lifesupportive care

Identifiers

PMID40803676
PMCPMC13033281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.