Evidence map›Paper›PMID 40803528›Full record

ArticleBrain stimulation

Analyses of biomarkers for tremor using local field potentials recorded from deep brain stimulation electrodes in the thalamus.

Karthik Kumaravelu, Stephen L Schmidt, Yi Zhao, Allison Vittert, Brandon D Swan, Chintan S Oza, Jennifer J Peters, Kyle T Mitchell, Dennis A Turner, Warren M Grill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karthik KumaraveluDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Stephen L SchmidtDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Yi ZhaoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Allison VittertDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Brandon D SwanDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Chintan S OzaDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Jennifer J PetersDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Kyle T MitchellDepartment of Neurology, Duke University Medical Center, Durham, NC, USA.
Dennis A TurnerDepartment of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC, USA; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Warren M GrillDepartment of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC, USA; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA. Electronic address: warren.grill@duke.edu.

Funding

Temporal Patterns of Deep Brain StimulationR37NS040894 · NINDS · DUKE UNIVERSITY · PI GRILL, WARREN M. · 2015 to 2021
$4.2M
An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson DiseaseUH3NS129898 · NINDS · DUKE UNIVERSITY · PI DENNIS Alan TURNER · 2023 to 2026
$3.7M
NINDS NIH HHS R37 NS040894NINDS NIH HHS UH3 NS129898
6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) of the thalamus (TH) is an effective therapy for suppressing tremor. One of the critical challenges to optimizing VIM-DBS therapy is the lack of robust neural biomarkers that correlate well with tremor.

objectiveTo quantify biomarkers for tremor using intraoperative TH local field potential (LFP) recorded from DBS electrodes. Further, we used computational modeling to understand the biophysical basis of the recorded LFP signal.

methodsWe simultaneously recorded intraoperative TH LFP and tremor from the hand dorsum (32 participants) and during DBS at different frequencies (16 participants). Then, we simulated the effects of DBS and spatial distribution of tremor cells on calculated LFPs in a TH model.

resultsThere was a moderate correlation between tremor and LFP spectral power in the theta and alpha bands (r = 0.445 and 0.389, respectively). There was a strong correlation between tremor and peak coherence between LFP and tremor signal (r = 0.559). Postural tremor was decoded from the LFP signal with an area under the curve of ∼0.7. High frequency DBS reduced spectral power in the theta and alpha bands and tremor could be decoded from the LFP spectral power in the presence of DBS (0.429 goodness of fit R

conclusionsTheta power alone was not sufficient for prediction of tremor control. Simulations indicated that the number and distribution of tremor cells surrounding the DBS lead may explain the lack of a strong correlation between tremor and theta power.

Indexed as

Deep Brain StimulationThalamusTremorVentral Thalamic NucleiAdultAgedBiomarkersFemaleHumansMaleMiddle AgedBiomarkersAlpha oscillationsDeep brain stimulationEssential tremorLocal field potentialsThetaVentral intermediate and ventralis oralis posterior nuclei of the thalamus

Identifiers

PMID40803528
PMCPMC12370280

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.