Evidence map›Paper›PMID 40803196›Full record

ArticleSeizure2025

Trauma and health-related quality of life in patients with functional seizures.

Jonah Fox, M Junaid Humayun, Madelyn K Bollig, Benjamin W Hopkins, Murli Mishra

Abstract read
In one paragraph

Article in Seizure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonah FoxDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address: jonah.fox@vumc.org.
M Junaid HumayunDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Madelyn K BolligDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Benjamin W HopkinsDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Murli MishraDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445
6 · The paper itself

Abstract

purposeTo assess the relationship between adverse life events and health-related quality of life in patients with functional seizures.

methodsWe recruited and consented patients with functional seizures who were admitted to the epilepsy monitoring unit and asked them to complete the Life Event Checklist for DSM-5 (LEC-5) and the 36-Item Short Form Health Survey (SF-36) to evaluate adverse life events and health-related quality of life, respectively. Additional variables were collected with a retrospective chart review. A multiple linear regression model was used to evaluate independent predictors of health-related quality of life.

resultsA total of 97 patients were included, and 98 % identified at least 1 adverse life event that was either witnessed or personally experienced. Health-related quality of life was poor compared to the general population. An increased number of types of witnessed or personally experienced adverse life events were associated with a worse mental component summary score and older age was associated with a worse physical component summary score. A longer duration of time with FS was associated with a better mental component summary score which may reflect some degree of adaptation or improved coping skills that developed over time.

conclusionOur study found that an increased burden of adverse life events in patients with functional seizures impacts health-related quality of life. These findings may have treatment and resource allocation implications.

Indexed as

Life Change EventsQuality of LifeSeizuresAdolescentAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesYoung AdultAbuseMorbidityPsychogenic non-epileptic seizuresStressTraumatic experiences

Identifiers

PMID40803196
PMCPMC13237828

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.