ArticleScience advances2025
Fourier synthesis optical diffraction tomography for kilohertz rate volumetric imaging.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A physics-informed alternative to Richardson-Lucy deconvolution across SNR regimes without iteration cutoffs.Nature communications · 2026Article
- Multimodal holotomography for volumetric monitoring of host-pathogen interactions.Biomedical engineering online · 2026Article
- Article
- Ultrafast tomograms in a flash.Science advances · 2025Review
- DMD and microlens array as a switchable module for illumination angle scanning in optical diffraction tomography.Biomedical optics express · 2024Article
- EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging.Light, science & applications · 2024Article
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Authors and funding
10 authors.
Funding
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Abstract
Many biological and soft matter processes occur at high speeds in complex three-dimensional (3D) environments, and developing imaging techniques capable of elucidating their dynamics is an outstanding challenge. Here, we introduce Fourier synthesis optical diffraction tomography (FS-ODT), a quantitative phase imaging approach capable of recording the 3D refractive index at kilohertz rates. FS-ODT introduces computational strategies that multiplex tens of illumination angles in a single tomogram, markedly increasing the volumetric imaging rate. We validate FS-ODT on samples of known composition, hindered diffusion of colloids in solution, and the motility of bacterial swimmers. We also integrate FS-ODT into a multimodal microscope combining refractive index imaging with multicolor structured illumination microscopy. FS-ODT is a promising approach for unlocking imaging regimes that have been little explored, including understanding the physical interactions of colloids and microswimmers with their 3D environment and the interplay between these stimuli and the molecular response of biological systems.
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