Evidence map›Paper›PMID 40802737›Full record

ArticleScience translational medicine2025

Proviruses in CD4

Fengting Wu, Milica Moskovljevic, Filippo Dragoni, Sahana Jayaraman, Nathan L Board, Angelica Camilo-Contreras, Silvia Bernal, Vivek Hariharan, Hao Zhang, Jun Lai and 13 more

Abstract read
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Fengting WuDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6320-8288
Milica MoskovljevicDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-0436-6854
Filippo DragoniDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-8148-9914
Sahana JayaramanInstitute of Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-3413-2530
Nathan L BoardDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-5208-9970
Angelica Camilo-ContrerasDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-5768-6312
Silvia BernalDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4991-0008
Vivek HariharanDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0000-7001-0077
Hao ZhangDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0009-0002-8314-5848
Jun LaiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0008-6435-2888
Anushka SinghalDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0004-4572-6697
Sebastien PoulinClinique L'Agora, Montréal, Québec H2L 4E9, Canada.ORCID 0009-0004-2822-3414
Frederic ChanoClinique L'Agora, Montréal, Québec H2L 4E9, Canada.ORCID 0009-0008-1685-3741
Annie ChamberlandCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec H2X 0A9, Canada.
Cecile TremblayCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec H2X 0A9, Canada.ORCID 0000-0002-3440-3436
Meredith ZoltickDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0009-4750-6803
Christopher J HoffmannDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Joyce L JonesDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-5882-0907
H Benjamin LarmanInstitute of Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-7863-196X
Luis J MontanerHIV Cure and Viral Diseases Center, Wistar Institute, Philadelphia, PA 19104, USA.ORCID 0000-0001-5799-6759
Janet D SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6712-3775
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1764-1993
Francesco R SimonettiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-4165-660X

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney CollaboratoryUM1AI164566 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Ann M Chahroudi, Deborah Persaud · 2021 to 2026
$35.5M
BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination ImmunotherapyUM1AI164570 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, James L. Riley · 2021 to 2026
$34.7M
Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0M
I4C 2.0: Immunotherapy for CureUM1AI164556 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Dan H. Barouch, John W Mellors · 2021 to 2026
$28.0M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Pharmacology and Molecular Sciences Training Program: Enhancing Inclusivity Through Universal Design for Learning in Graduate CoursesT32GM135083 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Caren L. Freel Meyers · 2020 to 2026
$3.3M
Investigating antigen-driven clonal proliferation to target HIV-1 persistenceDP5OD031834 · OD · JOHNS HOPKINS UNIVERSITY · PI SIMONETTI, FRANCESCO ROBERTO · 2021 to 2025
$2.0M
NIAID NIH HHS P30 AI094189NIAID NIH HHS UM1 AI126620NIAID NIH HHS UM1 AI164556NIAID NIH HHS UM1 AI164560NIAID NIH HHS UM1 AI164566NIAID NIH HHS UM1 AI164570NIGMS NIH HHS T32 GM135083NIH HHS DP5 OD031834
6 · The paper itself

Abstract

Antiretroviral therapy (ART) halts human immunodeficiency virus-1 (HIV-1) replication, reducing plasma virus concentrations to below the limit of detection, but it is not curative because of a reservoir of latently infected CD4

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV InfectionsProvirusesViremiaAdultFemaleHumansMaleMiddle AgedRNA, ViralVirus ReplicationRNA, Viral

Identifiers

PMID40802737
PMCPMC12363666

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.