Evidence map›Paper›PMID 40802678›Full record

ArticlePloS one2025

Association of oxidative stress biomarkers with primary congenital glaucoma.

Mingxi Shao, Yani Wan, Yingzhu Li, Yi Ma, Jun Ren, Shengjie Li, Wenjun Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Taurine in canine physiology and metabolic regulation.Frontiers in veterinary science · 2026
    Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mingxi ShaoDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yani WanDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yingzhu LiDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yi MaDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Jun RenDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Shengjie LiDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-6443-740X
Wenjun CaoDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo explore the relationship between oxidative stress biomarkers and primary congenital glaucoma (PCG).

methodsThis case-control study included 40 PCG patients and 38 matched controls. Serum total antioxidant status (TAS), as well as superoxide dismutase (SOD), malondialdehyde (MDA), reactive oxygen species (ROS) and hydrogen peroxide (H2O2) levels were measured, along with eye and body exams. Logistic regression analysis was performed for PCG risk factors and machine learning model biomarker diagnosis.

resultsIn the PCG group, H2O2 and MDA levels were notably higher than in controls (p < 0.001, p = 0.020), while TAS levels were significantly lower (p = 0.043). Adjusting for age and gender, the serum TAS (OR = 0.07, 95% CI 0.01-0.85, p = 0.037), H2O2 (OR = 1.21, 95% CI 1.09-1.35, p = 0.001) and MDA (OR = 1.17, 95% CI 1.00-1.34, p = 0.034) were determined to be independent risk/protective factors for PCG. Pearson analysis revealed significant negative correlations: SOD with anterior chamber depth (r = -0.445, p = 0.012) and H2O2 with mean deviation values for the visual field (r = -0.412, p = 0.041). Positive correlations were also significant: MDA with axial length (AL (r = 0.576, p = 0.002). The XGBoost or KNN model using TAS alone achieved the highest AUC (0.74) in five-fold cross-validation.

conclusionThe decrease in TAS levels and the increase in H2O2 and MDA levels are found to be correlated with PCG, and the results indicate that oxidative stress plays a part in congenital glaucoma onset.

Indexed as

BiomarkersGlaucomaOxidative StressAntioxidantsCase-Control StudiesChildFemaleHumansHydrogen PeroxideMaleMalondialdehydeReactive Oxygen SpeciesRisk FactorsSuperoxide DismutaseAntioxidantsBiomarkersHydrogen PeroxideMalondialdehydeReactive Oxygen SpeciesSuperoxide Dismutase

Identifiers

PMID40802678
PMCPMC12348995

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.