ArticleBioinformatics (Oxford, England)2025
NanoFilter: enhancing phasing performance by utilizing highly consistent INDELs and SNVs in nanopore sequencing.
Article in Bioinformatics (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Fragmentation of Long Reads Enables Reliable Mitogenome Assembly From Whole-Genome Amplification Data With Pervasive Palindromic Reads.Molecular ecology resources · 2026Article
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3 authors.
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Abstract
motivationNanopore sequencing data offer longer reads compared to other technologies, which is beneficial for phasing and genome assembly. INDELs provide valuable haplotype information and have significant potential to improve phasing performance. However, accurately identifying INDELs with variant callers is challenging, and incorporating INDELs into phasing remains a complex task. To address these issues, we developed NanoFilter, a novel filtering strategy designed to filter out INDELs that contain wrong phasing information based on their consistency.
resultsOur assessment using Nanopore R10 simplex data shows that filtering out low-consistency INDELs increases their precision from 88.3% to 98.8%, nearly matching the precision of SNVs. In the phasing results of Margin, incorporating these filtered INDELs leads to a 12.77% increase in N50 length and fewer switch errors. Furthermore, we found that SNVs filtered by NanoFilter will enhance assembly performance. When NanoFilter is integrated into the HapDup assembly pipeline, NanoFilter reduces the Hamming error rate and increases N50 length by 7.8%. AVAILABILITY AND IMPLEMENTATION: NanoFilter is available at https://github.com/Chenshanming-repo/NanoFilter (DOI: 10.5281/zenodo.16777826) and HapDup-NanoFilter is available at https://github.com/Chenshanming-repo/HapDup-NanoFilter (DOI: 10.5281/zenodo.16777890).
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