Evidence map›Paper›PMID 40802431›Full record

SynthesisRevista da Sociedade Brasileira de Medicina Tropical2025

Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil.

George Harisson Felinto Sampaio, Nathan Ravi Medeiros Honorato, Lucas Abrantes Batista, Maricélia de Aquino Santana, Carlos Ramon do Nascimento Brito, Rand Randall Martins, Paulo Marcos da Matta Guedes, Andressa Noronha Barbosa da Silva, Lúcia Maria da Cunha Galvão

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Revista da Sociedade Brasileira de Medicina Tropical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Long-Term Parasitological Clearance and Cardiac Progression inTropical medicine and infectious disease · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

George Harisson Felinto SampaioUniversidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Ciências da Saúde, Natal, RN, Brasil.ORCID http://orcid.org/0000-0001-9525-6532
Nathan Ravi Medeiros HonoratoUniversidade Federal de Minas Gerais, Programa de Pós-Graduação em Parasitologia, Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0002-5519-7926
Lucas Abrantes BatistaUniversidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Ciências da Saúde, Natal, RN, Brasil.ORCID http://orcid.org/0000-0001-5149-0909
Maricélia de Aquino SantanaUniversidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Ciências da Saúde, Natal, RN, Brasil.ORCID http://orcid.org/0000-0003-4218-3936
Carlos Ramon do Nascimento BritoUniversidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Biologia Parasitária, Natal, RN, Brasil.ORCID http://orcid.org/0000-0003-4882-5215
Rand Randall MartinsUniversidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Ciências Farmacêuticas, Natal, RN, Brasil.ORCID http://orcid.org/0000-0001-9668-0482
Paulo Marcos da Matta GuedesUniversidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Biologia Parasitária, Natal, RN, Brasil.ORCID http://orcid.org/0000-0002-4564-6791
Andressa Noronha Barbosa da SilvaUniversidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Ciências Farmacêuticas, Natal, RN, Brasil.ORCID http://orcid.org/0000-0002-6584-5771
Lúcia Maria da Cunha GalvãoUniversidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Ciências da Saúde, Natal, RN, Brasil.ORCID http://orcid.org/0000-0002-6207-4502

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genetic diversity of Trypanosoma cruzi and the epidemiological characteristics of the environments in which the parasite occurs are essential for understanding infection dynamics and controlling Chagas disease. This systematic review aimed to: (i) identify and analyze studies that evaluated the genetic variability and epidemiological aspects of T. cruzi infection in the state of Rio Grande do Norte, Brazil; (ii) summarize the information reported in the literature; and (iii) suggest new control strategies tailored to the region's epidemiological profile.

methodsFollowing the application of inclusion and exclusion criteria, 13 studies catalogued in PubMed, the Brazilian Virtual Health Library, Scopus, and the Web of Science were selected.

resultsT. cruzi isolates were primarily obtained from triatomine species Triatoma brasiliensis, Panstrongylus lutzi, and Triatoma pseudomaculata, as well as from wild mammals such as Euphractus sexcinctus, Galea spixii, and humans. A total of 295 T. cruzi isolates were genotyped: 46.5% (137) were identified as Discrete Typing Unit (DTU) I, 29.1% (86) as DTU II, and 20% (59) as DTU III. Mixed infections were detected in 4.4% (13/295) of hosts. Triatomine species were found in both peridomestic and intradomestic environments and were occasionally infected with T. cruzi.

conclusionsThis review provides a comprehensive overview of the circulation of distinct Trypanosoma cruzi genotypes (I, II, and III) in both wild and human-modified environments in Rio Grande do Norte.

Indexed as

Chagas DiseaseGenetic VariationInsect VectorsTriatominaeTrypanosoma cruziAnimalsBrazilGenotypeHumans

Identifiers

PMID40802431
PMCPMC12333620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.