ArticleRevista da Associacao Medica Brasileira (1992)2025
Prognostic factors of meningeal carcinomatosis in breast cancer patients.
Article in Revista da Associacao Medica Brasileira (1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aims to evaluate the primary signs and symptoms in patients diagnosed with breast cancer and meningeal carcinomatosismeningeal carcinomatosis, assess the prognostic role of these symptoms at the time of diagnosis, and correlate them with prognostic factors.
methodsThis retrospective study consecutively included breast cancer patients diagnosed with meningeal carcinomatosis. The study collected the symptoms of meningeal carcinomatosis at the time of diagnosis. To assess the prognostic role of symptoms in patients' overall survival, the Cox regression model was used.
resultsA total of 109 patients between the ages of 26 and 79 were included in the study. The most frequently reported symptoms at diagnosis were headache (42.2%), cranial nerve alteration (31.2%), and nausea (30.3%). The study showed a median survival of 2.4 months, with a 95% confidence interval of 1.7-3.0 months. The only symptom found to be associated with a worse prognosis was the presence of cranial nerve abnormalities, with a hazard ratio of 1.78 (95%CI 1.08-2.95, p=0.024). Conversely, the presence of meningeal hyperenhancement on magnetic resonance was related to a better prognosis, with an hazard ratio of 0.58 (p=0.02, 95%CI 0.36-0.92).
conclusionIt can be concluded that meningeal carcinomatosis is a serious condition, and the most common symptoms at diagnosis are headache and nausea. Special attention should be given to patients who present with alterations in cranial nerves, as they belong to a subgroup with a poor prognosis.
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