Evidence map›Paper›PMID 40802288›Full record

ArticleMolecular biology of the cell2025

Genetic dissection of the

Rebecca Stark, Caleb Dehn, Neelia Abadi, Yu Xiong, Landon Porter, Xun Chen, Dion Dickman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca StarkDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.
Caleb DehnDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.
Neelia AbadiDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.
Yu XiongDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.
Landon PorterDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.
Xun ChenDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.
Dion DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
NIH HHS P40 OD018537NINDS NIH HHS R01 NS091546
6 · The paper itself

Abstract

Neuronal trafficking pathways must operate with high fidelity and speed, adapting to the dynamic demands of synaptic activity to maintain stable functionality. The biogenesis of lysosome-related organelles complex 1 (BLOC-1) is an attractive candidate to stabilize synaptic function during such challenges. BLOC-1 is an evolutionarily conserved protein complex composed of eight subunits involved in vesicle trafficking. In the nervous system, the BLOC-1 is associated with neurodevelopmental diseases and synaptic plasticity. However, the functions of each BLOC-1 component remain enigmatic. Here, we use CRISPR to mutate each

Indexed as

Drosophila ProteinsNeuronal PlasticitySynapsesAnimalsDrosophilaDrosophila melanogasterHomeostasisMutationNeuromuscular JunctionNeuronsDrosophila Proteins

Identifiers

PMID40802288
PMCPMC12444909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.