Evidence map›Paper›PMID 40802235›Full record

ArticleMolecular diversity2026

Design, synthesis and SARS-CoV‑2 main protease inhibitory activities of 2-arylthiomethyl-6-bromoindole derivatives.

Zong Xinyu, Li Xiaoyang, Liu Shiyu, Jin Guanxuan, Yang Kan, Wang Chunnong, Li Longfei, Cao Fei, Li Wan

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zong XinyuKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China.
Li XiaoyangKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China.
Liu ShiyuKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China.
Jin GuanxuanKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China.
Yang KanKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China.
Wang ChunnongKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China.
Li LongfeiKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China.
Cao FeiKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China.
Li WanKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding, 071002, Hebei, People's Republic of China. liwan2015@hbu.edu.cn.

Funding

College Student Innovation and Entrepreneurship Training Program Project of Hebei Province DC2025330the Central Guidance for Local Scientific and Technological Development Funding Projects of Hebei Province No.236Z6505Gthe Excellent Youth Research Innovation Team of Hebei University No. QNTD202406the Foundation of President of Hebei University No. XZJJ202206the Innovation Team Project of Hebei University No. IT2023C01
6 · The paper itself

Abstract

COVID-19, caused by SARS-CoV-2, has led to a global health crisis. The main protease (M

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesDrug DesignIndolesProtease InhibitorsSARS-CoV-2AnimalsCOVID-19 Drug TreatmentHumansMiceMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAntiviral AgentsCoronavirus 3C ProteasesIndolesProtease Inhibitors2019-nCoV main protease2-Arylsulfanylmethyl-6-bromoindole derivativesDesign and synthesisMolecular dockingMolecular dynamics simulation

Identifiers

PMID40802235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.