Evidence map›Paper›PMID 40802219›Full record

ArticleNeurochemical research2025

TDAG51 Mediates Negative Signaling Crosstalk Between NGF/p75

Fernando Federicci, Fernanda Ledda, Gustavo Paratcha

Abstract read
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In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fernando FedericciLaboratorio de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencias (IBCN)-CONICET-UBA, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, CP1121, Argentina.ORCID http://orcid.org/0000-0002-6346-3518
Fernanda LeddaFundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA)-CONICET, Buenos Aires, Argentina.ORCID http://orcid.org/0000-0002-9769-6926
Gustavo ParatchaLaboratorio de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencias (IBCN)-CONICET-UBA, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, CP1121, Argentina. gparatcha@fmed.uba.ar.ORCID http://orcid.org/0000-0002-0804-4433

Funding

Argentine Agency for the Promotion of Science and Technology-ANPCyT PICT2019-1472Argentine Agency for the Promotion of Science and Technology-ANPCyT PICT2019-4597Fellowship from Argentine Agency for the Promotion of Science and Technology-ANPCyT PICT2021-00627National Council of Scientific and Technical Research-CONICET IBCN-P-UE 2018-22920180100009
6 · The paper itself

Abstract

GDNF is a potent survival and differentiation factor for motor neurons and other central and peripheral neuronal populations. While the signaling pathways by which GDNF promotes survival/differentiation have been relatively well established, the molecular mechanisms that restrict its biological effects remain unclear. In this study, we show that TDAG51 plays a role in regulating the GDNF-induced PI3K/AKT survival pathway. Our findings demonstrate that treatment of motor neuron-derived MN1 cells with high levels of nerve growth factor (NGF), a treatment that under oxidative conditions promotes p75 neurotrophin receptor (p75

Indexed as

Glial Cell Line-Derived Neurotrophic FactorMotor NeuronsNerve Growth FactorProto-Oncogene Proteins c-retReceptors, Nerve Growth FactorSignal TransductionAnimalsApoptosisCell DeathCell LineCell SurvivalMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsGlial Cell Line-Derived Neurotrophic FactorNerve Growth FactorPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-retReceptors, Nerve Growth FactorAKT pathwayGDNF/RET signalingNeurotrophic factorsP75NTR and apoptotic cell deathTDAG51

Identifiers

PMID40802219

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.