Observational studyIrish journal of medical science2025
Nutritional status and frailty in elderly patients undergoing major abdominal surgery for upper gastrointestinal tumors: a single-center prospective observational study.
Observational study in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Predicting need for step-up approach and recurrence in endoscopic management of anastomotic strictures after esophagectomy: results from a 10-year multicenter retrospective study.Surgical endoscopy · 2026Article
- Tree-based model for diffuse-type gastric cancer prognostication: a population study based on the Surveillance, Epidemiology, and End Results database.Translational cancer research · 2026Article
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Authors and funding
5 authors.
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Abstract
backgroundMalnutrition and frailty are significant health issues that can result in poor postoperative outcomes for elderly surgical patients.
aimThis prospective observational study aimed to explore the relationship between frailty, nutritional status, and postoperative outcomes in elderly patients undergoing abdominal surgery for upper gastrointestinal tumors.
methodsThe study included 72 elderly patients (38 frail, 34 pre-frail). All patients were interviewed face-to-face before the surgery, at discharge, and on the 30th day post-discharge. FRAIL was used to determine frailty, and those ≥ 3 were considered 'frail'. Anthropometric measurements and biochemical parameters were recorded during each interview. Additionally, nutritional status was determined by the Mini Nutritional Assessment (MNA), and 3-day food records were also collected.
resultsFrail patients (Median:18 days) experienced longer perioperative hospital stays compared to pre-frail (Median:14 days) (p < 0.001) and had a higher incidence of postoperative complications (p = 0.029). In addition to the MNA score (p < 0.001), mid-upper arm circumference (MUAC) (p < 0.001), calf circumference (CC) (p < 0.001), triceps skinfold thickness (p < 0.05), and handgrip strength (HGS) (p < 0.001) were found to be lower in frail patients at every interview. Albumin, calcium, and magnesium levels were also lower in frail patients (p < 0.001). Additionally, frail patients had significantly lower energy, protein, and calcium intake (p < 0.001), and they were also below the recommended levels. FRAIL score was positively correlated with age, number of comorbidities, medications (p < 0.001), and length of hospitalization (p < 0.05), and negatively correlated with CC, MUAC (p < 0.001), HGS (p < 0.05), MNA, dietary energy, protein, and calcium intake, as well as serum calcium and albumin levels (p < 0.001). MNA score (p = 0.045), serum albumin level (p = 0.022), and dietary energy intake (p < 0.001) were significant determinants of the FRAIL score according to the multiple linear regression.
conclusionsThis study found that frailty is associated with malnutrition and adverse surgical outcomes in elderly patients. The results underline the importance of the assessment of frailty and nutritional status in both pre- and postoperative periods.
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