Evidence map›Paper›PMID 40802140›Full record

ArticleDigestive diseases and sciences2025

Plummer-Vinson Syndrome: A Retrospective Multicenter Study.

Ahmed Elsayed Alzamzamy, Mohammed Tag-Adeen, Abdullah Zuhair Alyouzbaki, Sameh A Lashen, Walid Ismail Ellakany, Hussein Hassan Okasha, Dalia Abdelfatah, Hazem Abosheaishaa, Ahmed El-Borollosy, Krishn Kant Rawal

Abstract readMulticenter Study
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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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10 authors.

Ahmed Elsayed AlzamzamyDepartment of Gastroenterology and Hepatology, Military Medical Academy, Cairo, Egypt.
Mohammed Tag-AdeenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Abdullah Zuhair AlyouzbakiDepartment of Gastroenterology, College of Medicine, University of Mosul, Mosul, Iraq.
Sameh A LashenDivision of Hepatology and Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Walid Ismail EllakanyDepartment of Tropical Medicine, Alexandria University, Alexandria, Egypt.
Hussein Hassan OkashaDepartment of Internal Medicine and Hepatogastroenterology, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
Dalia AbdelfatahCancer Epidemiology and Biostatistics Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Hazem AbosheaishaaDepartment of Internal Medicine, Icahn School of Medicine at Mount Sinai / NYC Health + Hospitals Queens, New York, USA. hazemabosheaishaa@gmail.com.
Ahmed El-BorollosyDepartment of Internal Medicine, Modern University for Technology and Information, Cairo, Egypt.
Krishn Kant RawalDepartment of Gastroenterology, Prime Institute of Digestive Sciences, Rajkot, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlummer-Vinson syndrome (PVS) is a rare disorder characterized by post-cricoid dysphagia, iron deficiency anemia (IDA), and upper esophageal web formation. Despite its clinical significance and potential progression to esophageal squamous cell carcinoma (SCC), data on PVS remain limited. This study aims to analyze the demographic, clinical, imaging characteristics, and treatment outcomes of PVS across multiple centers.

methodsA retrospective, multicenter study was conducted across seven high-volume tertiary GI endoscopy centers in Egypt, India, and Iraq between 2021 and 2024. Medical records of consecutive patients diagnosed with PVS, based on the presence of post-cricoid dysphagia, IDA, and upper esophageal web, were reviewed. Clinical data, laboratory investigations, imaging findings, and treatment modalities were analyzed.

resultsA total of 56 patients were included, with a mean age of 41 ± 17 years; 80.5% were female. Post-cricoid dysphagia and IDA were present in all cases, with a mean hemoglobin level of 8.2 ± 1.5 g/dL and serum ferritin of 10.34 ± 5.2 ng/mL. Coeliac disease was the most common associated condition (10.7%). Endoscopic dilation was the primary treatment, with Savary-Gilliard bougie dilators used in 89% of cases. A single dilation session was sufficient in 76.8% of patients. During follow-up, 7.1% developed esophageal SCC/dysplasia. No significant post-dilation complications were observed.

conclusionPVS predominantly affects middle-aged women and is strongly associated with IDA. Endoscopic dilation is an effective treatment, with most patients responding to a single session. Given the potential risk of malignant transformation, close monitoring is essential. Further research is needed to elucidate pathogenesis and optimize management strategies for PVS.

Indexed as

Anemia, Iron-DeficiencyDeglutition DisordersPlummer-Vinson SyndromeAdultAgedEgyptFemaleHumansMaleMiddle AgedRetrospective StudiesDysphagiaEndoscopic dilationEsophageal cancerEsophageal webIron deficiency anemiaPlummer-Vinson syndrome

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PMID40802140

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