Evidence map›Paper›PMID 40802112›Full record

ArticleCellular and molecular life sciences : CMLS2025

KRAS4B is required for placental development.

Marie-Albane Minati, Leyre López Muneta, Younes Achouri, Sophie Pirenne, Corentin Porada, Francesca Rochais, Patrick Jacquemin

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marie-Albane MinatiUniversité Catholique de Louvain, de Duve Institute, Brussels, Belgium.
Leyre López MunetaUniversité Catholique de Louvain, de Duve Institute, Brussels, Belgium.
Younes AchouriUniversité Catholique de Louvain, de Duve Institute, Brussels, Belgium.
Sophie PirenneUniversité Catholique de Louvain, de Duve Institute, Brussels, Belgium.
Corentin PoradaAix-Marseille Université, INSERM, Marseille Medical Genetics, Marseille, France.
Francesca RochaisAix-Marseille Université, INSERM, Marseille Medical Genetics, Marseille, France.
Patrick JacqueminUniversité Catholique de Louvain, de Duve Institute, Brussels, Belgium. patrick.jacquemin@uclouvain.be.ORCID http://orcid.org/0000-0002-8781-6453

Funding

Fonds De La Recherche Scientifique - FNRS J.0085.19
6 · The paper itself

Abstract

Beyond its well-established role in cancer, KRAS is also crucial for embryogenesis, as its absence leads to embryonic lethality. However, the precise mechanisms underlying the developmental functions of KRAS, as well as the respective roles of its two splicing isoforms, KRAS4A and KRAS4B, remain incompletely characterized. To address these issues, we generated Kras4A knock-out (Kras4A

Indexed as

PlacentaPlacentationProto-Oncogene Proteins p21(ras)AnimalsCRISPR-Cas SystemsFemaleMiceMice, KnockoutPhenotypePregnancyTrophoblastsHras protein, mouseProto-Oncogene Proteins p21(ras)DevelopmentHeartKRAS4AKRAS4BPlacenta

Identifiers

PMID40802112
PMCPMC12350891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.