Evidence map›Paper›PMID 40802092›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

In vivo optoacoustic imaging of endothelin receptor expression and treatment response in the hypoxic tumor microenvironment.

Carsten Höltke, Moushami Mallik, Miriam Stölting, Emily Hoffmann, Christiane Geyer, Raghu Erapaneedi, Friedemann Kiefer, Anne Helfen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carsten Höltke *Clinic for Radiology, University of Muenster and University Hospital Muenster, Muenster, Germany.ORCID 0000-0001-5705-1130
Moushami Mallik *Clinic for Radiology, University of Muenster and University Hospital Muenster, Muenster, Germany.ORCID 0000-0002-0970-7411
Miriam StöltingClinic for Radiology, University of Muenster and University Hospital Muenster, Muenster, Germany.
Emily HoffmannClinic for Radiology, University of Muenster and University Hospital Muenster, Muenster, Germany.
Christiane GeyerClinic for Radiology, University of Muenster and University Hospital Muenster, Muenster, Germany.
Raghu ErapaneediEuropean Institute for Molecular Imaging (EIMI), Multiscale Imaging Centre (MIC), University of Muenster, Muenster, Germany.
Friedemann KieferEuropean Institute for Molecular Imaging (EIMI), Multiscale Imaging Centre (MIC), University of Muenster, Muenster, Germany.
Anne HelfenClinic for Radiology, University of Muenster and University Hospital Muenster, Muenster, Germany. anne.helfen@ukmuenster.de.ORCID 0000-0001-5894-2365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA hypoxic tumor microenvironment promotes cancer progression, with endothelin-A receptor (ET

methodsA fluorescent ET

resultsExposure of 4T1 murine breast cancer cells to hypoxic conditions led to upregulation of ET

conclusionET

Indexed as

Gene Expression Regulation, NeoplasticPhotoacoustic TechniquesReceptor, Endothelin ATumor HypoxiaTumor MicroenvironmentAnimalsCell Line, TumorFemaleMiceTreatment OutcomeReceptor, Endothelin AEndothelin systemIn vivo imagingOptoacoustic tomographyTumor hypoxiaTumor microenvironment

Identifiers

PMID40802092
PMCPMC12830490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.